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- W1973370122 abstract "Abstract. The clinical significance of some red cell alloantibodies remains in doubt and can best be studied with long-term 51Cr survival studies. We report a patient whose IgG anti-Yta was initially shown not to shorten the lifespan of 51Cr-labeled Yt(a+) red cells. At the time of this study, the subclass of the antibody could not be determined. Twelve weeks after transfusion with 4 units of Yt(a+) red cells, the alloantibody for the first time was demonstrable as IgG1; a repeat radiolabeled red cell survival demonstrated significant shortening of the lifespan of Yt(a+) red cells when they were followed for 7 days. These cells had a marked ‘two-component’ survival curve. Because the patient also demonstrated autoantibody coating his red cells, the clinical effect of this autoantibody was followed with autologous red cells labeled with 111In; the survival of autologous red cells was normal throughout these studies. Evaluation of the clinical significance of an alloantibody in a patient may require long-term 51Cr red cell survival studies and repetition of these studies after exposure to large quantities of the antigen." @default.
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- W1973370122 date "1988-10-01" @default.
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- W1973370122 title "An Example of Anti-Yt<sup>a</sup>Demonstrating a Change in Its Clinical Significance" @default.
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- W1973370122 doi "https://doi.org/10.1111/j.1423-0410.1988.tb05087.x" @default.
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