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• W1973374000 abstract "Abstract The influence of repeated exposure to and subsequent withdrawal from diazepam and bromazepam treatment was studied on precursor tyrosine as well as the levels of norepinephrine, dopamine and its metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid in rat brain. Administration of diazepam and bromazepam for 22 days suppressed spontaneous locomotor activity to 39% and 51% respectively, but produced no change in body weights and striatal tyrosine levels. Chronic therapy with either of the two anxiolytic agents significantly enhanced the concentration of norepinephrine and dopamine in several regions of the brain examined. In contrast, treatment with these benzodiazephines decreased the levels of striatal homovanillic acid when compared with the control values. Data suggest that these minor tranquilizers may manifest their taming effect by decreasing the physiological release and subsequent lowering of catecholamines in the vicinity of corresponding receptors. Forty-eight hour withdrawal in rats subjected to chronic diazepam and bromazepam treatment elevated the spontaneous locomotor activity by 228% and 153% respectively, the values being significantly greater than even those seen for normal control rats. Furthermore, the levels of norepinephrine and dopamine were significantly decreased in cerebral cortex, hypothalamus, pons-medulla, mid-brain and striatum presumably due to massive release of these neurohumors. Withdrawal from these psychotropic drugs also enhanced the levels of striatal homovanillic acid which is formed as a result of extraneuronal (functional) metabolism of dopamine. The present results may constitute a neurochemical basis for the role of dopamine and possibly norepinephrine in “rebound” phenomenon seen clinically as well as in laboratory animals during the “withdrawal” phase from benzodiazepine therapy." @default.
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• W1973374000 title "Evidence for the role of brain norepinephrine and dopamine in “rebound” phenomenon seen during withdrawal after repeated exposure to benzodiazepines" @default.
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• W1973374000 doi "https://doi.org/10.1016/0022-3956(77)90009-7" @default.
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