Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973381319> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1973381319 endingPage "1114" @default.
- W1973381319 startingPage "1114" @default.
- W1973381319 abstract "Previous studies have demonstrated the rapid increase in systemic capillary permeability after blunt trauma and its association with poor outcome. There are theoretical advantages in resuscitation with colloid fluids, which are well retained in the vascular compartment during times of capillary leak. The aim of this study was to compare the effects of posttrauma resuscitation with hydroxyethyl starch (HES) (molecular mass, 250 kDa) or gelatine (molecular mass, 30 kDa), the hypothesis being that HES would reduce capillary leak.Forty-five patients suffering blunt trauma were randomized on admission to receive either gelatine (Gelofusine) (n = 21) or HES (Pentaspan) (n = 24) for the first 24 hours, after which the choice of fluid was at the discretion of the clinician. The mean Injury Severity Score for the HES and gelatine groups were 20.0 (range, 9-41) and 18.1 (range, 9-32), respectively (p = 0.43). Capillary permeability was assessed by urine albumin excretion rate for the first 24 hours. For 5 days the daily mean P(O2)/F(IO2) ratio, serum C-reactive protein, hemoglobin, white cell and platelet counts, prothrombin, and activated partial thromboplastin time were recorded.Capillary permeability was lower in HES-treated patients during the first 24 hours. Log mean (95% confidence interval) albumin excretion rate for gelatine and HES groups at 6 hours were 117.5 (84.9) and 46.8 (24.3) microg/min (p = 0.011), at 12 hours were 54.9 (30.0) and 17.2 (7.6) microg/min (p = 0.001), and at 24 hours were 50.5 (23.4) and 23.6 (16.3) microg/min (p = 0.030), respectively. The mean (95% confidence interval) P(O2)/F(IO2) ratio for the HES and gelatine groups 48 hours after admission were 324 (44) and 267 (43) mm Hg, respectively (p = 0.03). The mean (95% confidence interval) serum C-reactive protein in the HES and gelatine groups 24 hours after admission were 72.4 (19.2) and 105.7 (30.1) mg/L, respectively (p = 0.03). There were no significant differences in any of the hematologic parameters during the first 48 hours.The results suggest that compared with gelatine, resuscitation with HES reduces posttrauma capillary leak." @default.
- W1973381319 created "2016-06-24" @default.
- W1973381319 creator A5010729882 @default.
- W1973381319 creator A5026389650 @default.
- W1973381319 creator A5035734746 @default.
- W1973381319 creator A5048226565 @default.
- W1973381319 creator A5057724022 @default.
- W1973381319 date "1999-12-01" @default.
- W1973381319 modified "2023-10-18" @default.
- W1973381319 title "Randomized Trial of Hydroxyethyl Starch versus Gelatine for Trauma Resuscitation" @default.
- W1973381319 cites W1972567438 @default.
- W1973381319 cites W1983026424 @default.
- W1973381319 cites W2014261846 @default.
- W1973381319 cites W20181957 @default.
- W1973381319 cites W2026195878 @default.
- W1973381319 cites W2030346204 @default.
- W1973381319 cites W2045041613 @default.
- W1973381319 cites W2053631367 @default.
- W1973381319 cites W2077568216 @default.
- W1973381319 cites W2113192265 @default.
- W1973381319 cites W2130713902 @default.
- W1973381319 cites W2139501018 @default.
- W1973381319 cites W2272679087 @default.
- W1973381319 cites W2429779286 @default.
- W1973381319 cites W4239945596 @default.
- W1973381319 cites W4242433072 @default.
- W1973381319 cites W4247810543 @default.
- W1973381319 cites W4251622760 @default.
- W1973381319 cites W4301459522 @default.
- W1973381319 cites W1983357509 @default.
- W1973381319 doi "https://doi.org/10.1097/00005373-199912000-00023" @default.
- W1973381319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10608543" @default.
- W1973381319 hasPublicationYear "1999" @default.
- W1973381319 type Work @default.
- W1973381319 sameAs 1973381319 @default.
- W1973381319 citedByCount "111" @default.
- W1973381319 countsByYear W19733813192012 @default.
- W1973381319 countsByYear W19733813192013 @default.
- W1973381319 countsByYear W19733813192014 @default.
- W1973381319 countsByYear W19733813192015 @default.
- W1973381319 countsByYear W19733813192016 @default.
- W1973381319 countsByYear W19733813192017 @default.
- W1973381319 countsByYear W19733813192018 @default.
- W1973381319 crossrefType "journal-article" @default.
- W1973381319 hasAuthorship W1973381319A5010729882 @default.
- W1973381319 hasAuthorship W1973381319A5026389650 @default.
- W1973381319 hasAuthorship W1973381319A5035734746 @default.
- W1973381319 hasAuthorship W1973381319A5048226565 @default.
- W1973381319 hasAuthorship W1973381319A5057724022 @default.
- W1973381319 hasConcept C113045295 @default.
- W1973381319 hasConcept C126322002 @default.
- W1973381319 hasConcept C141071460 @default.
- W1973381319 hasConcept C185592680 @default.
- W1973381319 hasConcept C2776125364 @default.
- W1973381319 hasConcept C2778165595 @default.
- W1973381319 hasConcept C2778261982 @default.
- W1973381319 hasConcept C2779412105 @default.
- W1973381319 hasConcept C2780434524 @default.
- W1973381319 hasConcept C42219234 @default.
- W1973381319 hasConcept C71924100 @default.
- W1973381319 hasConcept C89560881 @default.
- W1973381319 hasConceptScore W1973381319C113045295 @default.
- W1973381319 hasConceptScore W1973381319C126322002 @default.
- W1973381319 hasConceptScore W1973381319C141071460 @default.
- W1973381319 hasConceptScore W1973381319C185592680 @default.
- W1973381319 hasConceptScore W1973381319C2776125364 @default.
- W1973381319 hasConceptScore W1973381319C2778165595 @default.
- W1973381319 hasConceptScore W1973381319C2778261982 @default.
- W1973381319 hasConceptScore W1973381319C2779412105 @default.
- W1973381319 hasConceptScore W1973381319C2780434524 @default.
- W1973381319 hasConceptScore W1973381319C42219234 @default.
- W1973381319 hasConceptScore W1973381319C71924100 @default.
- W1973381319 hasConceptScore W1973381319C89560881 @default.
- W1973381319 hasIssue "6" @default.
- W1973381319 hasLocation W19733813191 @default.
- W1973381319 hasLocation W19733813192 @default.
- W1973381319 hasOpenAccess W1973381319 @default.
- W1973381319 hasPrimaryLocation W19733813191 @default.
- W1973381319 hasRelatedWork W1857288271 @default.
- W1973381319 hasRelatedWork W2029341269 @default.
- W1973381319 hasRelatedWork W2046616754 @default.
- W1973381319 hasRelatedWork W2110223924 @default.
- W1973381319 hasRelatedWork W2128846056 @default.
- W1973381319 hasRelatedWork W2373461619 @default.
- W1973381319 hasRelatedWork W2596226778 @default.
- W1973381319 hasRelatedWork W2811413127 @default.
- W1973381319 hasRelatedWork W3030077690 @default.
- W1973381319 hasRelatedWork W4211117411 @default.
- W1973381319 hasVolume "47" @default.
- W1973381319 isParatext "false" @default.
- W1973381319 isRetracted "false" @default.
- W1973381319 magId "1973381319" @default.
- W1973381319 workType "article" @default.