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- W1973392010 abstract "Abstract The effects of Δ 1 -THC and of SP-111, a water-soluble Δ 1 -THC derivative, on spontaneous cellular activity and responsiveness to afferent stimulation were studied in the hippocampus of the awake rat. The effects of SP-111 on spontaneous and neurotransmitter-induced changes in neuronal activity in anesthetized rat cerebellum and hippocampus were studied with the method of microiontophoresis. When applied parenterally into the awake rat, SP-111 caused behavioral changes similar to those seen after a Δ 1 -THC injection. In addition, it caused a reduction of spontaneous activity of cells in the hippocampus with a single-spike firing pattern without affecting firing of bursting neurons. Furthermore, the averaged evoked field responses to commissural stimulation were reduced by a third up to 2–3 h after the injection. High phoretic currents (100 nA) of SP-111 reduced spontaneous activity of cerebellar and hippocampal neurons. Lower currents potentiated cerebellar inhibitory responses to iontophoretically applied norepinephrine. Even lower currents (50 nA) potentiated responses to iontophoretically applied GABA in the cerebellum. The most potent effect of SP-111 was the antagonism of aspartate-induced excitation of cells in the hippocampus. It is suggested that SP-111 antagonizes an acidic amino acid neurotransmitter in several synapses of the rat hippocampus, and that it may also potentiate the efficacy of transmission in GABAergic and noradrenergic synapses." @default.
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- W1973392010 date "1978-01-01" @default.
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- W1973392010 title "The effects of SP-111, a water-soluble THC derivative, on neuronal activity in the rat brain" @default.
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- W1973392010 doi "https://doi.org/10.1016/0006-8993(78)90928-9" @default.
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