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- W1973395347 endingPage "95" @default.
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- W1973395347 abstract "Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages. Thus, the development of safer and potentially promising protease inhibitors is eagerly needed. In this review, we introduced the chemical characteristics and associated side effects of HIV protease inhibitors, as well as the possible off-target mechanisms causing the side effects. From the chemical structures of HIV protease inhibitors and their possible off-target molecules, we could obtain hints for optimizing the molecular selectivity of the inhibitors, to provide help in the design of new compounds with enhanced bioavailability and reduced side effects." @default.
- W1973395347 created "2016-06-24" @default.
- W1973395347 creator A5030876549 @default.
- W1973395347 creator A5052801053 @default.
- W1973395347 creator A5066102428 @default.
- W1973395347 date "2015-04-01" @default.
- W1973395347 modified "2023-10-15" @default.
- W1973395347 title "HIV protease inhibitors: a review of molecular selectivity and toxicity" @default.
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- W1973395347 doi "https://doi.org/10.2147/hiv.s79956" @default.
- W1973395347 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4396582" @default.
- W1973395347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25897264" @default.
- W1973395347 hasPublicationYear "2015" @default.
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