Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973397356> ?p ?o ?g. }
- W1973397356 endingPage "65" @default.
- W1973397356 startingPage "53" @default.
- W1973397356 abstract "Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs). It becomes clinically apparent in >30% of patients with Crohn’s disease (CD) and in about 5% with ulcerative colitis (UC). Fibrosis is a consequence of local chronic inflammation and is characterized by excessive extracellular matrix (ECM) protein deposition. ECM is produced by activated myofibroblasts, which are modulated by both, profibrotic and antifibrotic factors. Fibrosis depends on the balance between the production and degradation of ECM proteins. This equilibrium can be impacted by a complex and dynamic interaction between profibrotic and antifibrotic mediators. Despite the major therapeutic advances in the treatment of active inflammation in IBD over the past two decades, the incidence of intestinal strictures in CD has not significantly changed as the current anti-inflammatory therapies neither prevent nor reverse the established fibrosis and strictures. This implies that control of intestinal inflammation does not necessarily affect the associated fibrotic process. The conventional view that intestinal fibrosis is an inevitable and irreversible process in patients with IBD is also gradually changing in light of an improved understanding of the cellular and molecular mechanisms that underline the pathogenesis of fibrosis. Comprehension of the mechanisms of intestinal fibrosis is thus vital and may pave the way for the developments of antifibrotic agents and new therapeutic approaches in IBD." @default.
- W1973397356 created "2016-06-24" @default.
- W1973397356 creator A5005626026 @default.
- W1973397356 creator A5011273738 @default.
- W1973397356 creator A5012305407 @default.
- W1973397356 creator A5022554913 @default.
- W1973397356 creator A5026242246 @default.
- W1973397356 date "2014-12-19" @default.
- W1973397356 modified "2023-10-05" @default.
- W1973397356 title "Mechanisms of initiation and progression of intestinal fibrosis in IBD" @default.
- W1973397356 cites W1489063373 @default.
- W1973397356 cites W1532872348 @default.
- W1973397356 cites W1579159557 @default.
- W1973397356 cites W1597773971 @default.
- W1973397356 cites W1925728463 @default.
- W1973397356 cites W1963625450 @default.
- W1973397356 cites W1967692138 @default.
- W1973397356 cites W1970846514 @default.
- W1973397356 cites W1974009609 @default.
- W1973397356 cites W1976325389 @default.
- W1973397356 cites W1980401378 @default.
- W1973397356 cites W1981828551 @default.
- W1973397356 cites W1982722982 @default.
- W1973397356 cites W1984119315 @default.
- W1973397356 cites W1989819959 @default.
- W1973397356 cites W1992911324 @default.
- W1973397356 cites W1993345123 @default.
- W1973397356 cites W1993600822 @default.
- W1973397356 cites W1994083978 @default.
- W1973397356 cites W1994713876 @default.
- W1973397356 cites W1997413662 @default.
- W1973397356 cites W1998302810 @default.
- W1973397356 cites W1999395941 @default.
- W1973397356 cites W2000073606 @default.
- W1973397356 cites W2001807095 @default.
- W1973397356 cites W2004301008 @default.
- W1973397356 cites W2006778392 @default.
- W1973397356 cites W2007406330 @default.
- W1973397356 cites W2019087148 @default.
- W1973397356 cites W2019558732 @default.
- W1973397356 cites W2025026333 @default.
- W1973397356 cites W2025335044 @default.
- W1973397356 cites W2027929073 @default.
- W1973397356 cites W2032899857 @default.
- W1973397356 cites W2034817600 @default.
- W1973397356 cites W2035029345 @default.
- W1973397356 cites W2037478126 @default.
- W1973397356 cites W2044183928 @default.
- W1973397356 cites W2045142779 @default.
- W1973397356 cites W2051692635 @default.
- W1973397356 cites W2055309486 @default.
- W1973397356 cites W2056323683 @default.
- W1973397356 cites W2056716376 @default.
- W1973397356 cites W2059114286 @default.
- W1973397356 cites W2060643376 @default.
- W1973397356 cites W2063053901 @default.
- W1973397356 cites W2063628403 @default.
- W1973397356 cites W2065601913 @default.
- W1973397356 cites W2069522492 @default.
- W1973397356 cites W2075032773 @default.
- W1973397356 cites W2079363030 @default.
- W1973397356 cites W2079517510 @default.
- W1973397356 cites W2080347540 @default.
- W1973397356 cites W2083759302 @default.
- W1973397356 cites W2083893575 @default.
- W1973397356 cites W2087544898 @default.
- W1973397356 cites W2091934134 @default.
- W1973397356 cites W2095407038 @default.
- W1973397356 cites W2098301759 @default.
- W1973397356 cites W2102087425 @default.
- W1973397356 cites W2102490423 @default.
- W1973397356 cites W2105264433 @default.
- W1973397356 cites W2106733239 @default.
- W1973397356 cites W2107158136 @default.
- W1973397356 cites W2107994524 @default.
- W1973397356 cites W2108213314 @default.
- W1973397356 cites W2113690494 @default.
- W1973397356 cites W2121894364 @default.
- W1973397356 cites W2124979919 @default.
- W1973397356 cites W2128452827 @default.
- W1973397356 cites W2135032227 @default.
- W1973397356 cites W2135871041 @default.
- W1973397356 cites W2139402558 @default.
- W1973397356 cites W2142082253 @default.
- W1973397356 cites W2146481308 @default.
- W1973397356 cites W2148183537 @default.
- W1973397356 cites W2149171832 @default.
- W1973397356 cites W2150355840 @default.
- W1973397356 cites W2151260549 @default.
- W1973397356 cites W2152841886 @default.
- W1973397356 cites W2154175192 @default.
- W1973397356 cites W2159395450 @default.
- W1973397356 cites W2160911117 @default.
- W1973397356 cites W2160969462 @default.
- W1973397356 cites W2161738612 @default.
- W1973397356 cites W2162313829 @default.
- W1973397356 cites W2163083170 @default.
- W1973397356 cites W2164004499 @default.