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• W1973401035 abstract "<b><i>Objectives:</i></b> Since it has been reported that in humans there is a relationship between human respiratory syncytial virus (hRSV)-specific cytotoxic T lymphocytes and symptom reduction, and that the polymerase (structural L protein) is highly conserved among different strains, this work aimed to identify the CD8 T cell epitopes H-2^d restricted within the L sequence for immunization purposes. <b><i>Methods:</i></b> We screened the hRSV strain A2 L protein sequence using two independent algorithms, SYFPEITHI and PRED/^BALB/c, to predict CD8 T cell epitopes. The selected peptides were synthesized and used to immunize BALB/c mice for the evaluation of T cell response. The production of IFN-&#947; from splenocytes of hRSV-infected animals stimulated by these peptides was assayed by ELISPOT. <b><i>Results:</i></b> Nine peptides showing the best binding scores to the BALB/c MHC-I molecules (H-2K^d, L^d and D^d) were selected. Sequence homology analysis showed that these sequences are conserved among different hRSV strains. Two of these peptides induced significant IFN-&#947; production by ex vivo-stimulated T cells. <b><i>Conclusions:</i></b> Our results indicate that the hRSV L protein contains H-2^d-restricted epitopes." @default.
• W1973401035 created "2016-06-24" @default.
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• W1973401035 date "2014-01-01" @default.
• W1973401035 modified "2023-10-18" @default.
• W1973401035 title "Mapping of CD8 T Cell Epitopes in Human Respiratory Syncytial Virus L Protein" @default.
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• W1973401035 doi "https://doi.org/10.1159/000357325" @default.
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