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- W1973402024 abstract "Abstract The process of carcinogenesis involves multiple events of which activation of oncogenes is of utmost importance. In order to study the mechanisms involved in NDEA and NDEA-PB-mediated liver carcinogenesis an attempt has been made to analyze the mutational activation of c-Ha-ras proto-oncogene and overexpression of c-jun and c-myc oncogenes. Mutation in both the exons (exon I and II) of c-Ha-ras oncogene was detected by polymerase chain reaction (PCR) and single strand conformational polymorphism (SSCP). The frequency of mutation of c-Ha-ras oncogene in hepatocarcinogenesis increases with the increase in duration of NDEA treatment. But no mutation is observed in any duration of NDEA-PB-mediated hepatocarcinogenesis. The overexpression of c-jun and c-myc by northern blot hybridization indicate both the oncogenes are overexpressed in NDEA and NDEA-PB-mediated hepatocarcinogenesis and has an increasing pattern with increase in duration of treatment. Thus, the overexpression of c-jun and c-myc can be switched on by mutational activation of c-Ha-ras oncogene in NDEA and by phenobarbital in NDEA-PB mediated hepatocarcinogenesis. Such activation of c-myc and c-jun is suggested further to play a crucial role in the pathogenesis of liver cancer." @default.
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- W1973402024 date "1999-10-01" @default.
- W1973402024 modified "2023-09-27" @default.
- W1973402024 title "Mutational activation of c-Ha-ras oncogene or cancer promotion by phenobarbital upregulates the transcription of c-jun and c-myc oncogene in N-nitrosodiethylamine-mediated hepatocarcinogenesis" @default.
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- W1973402024 doi "https://doi.org/10.1016/s1386-6346(99)00018-2" @default.
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