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- W1973402376 abstract "ABSTRACT Objective To study the effect of placental insufficiency on fetal lymphocyte subpopulations. Study design Cross sectional study of 19 growth retarded fetuses undergoing cordocentesis at 24 to 37 weeks gestation. Flow cytometry was used to enumerate fetal blood lymphocyte subpopulations. Results The mean T (CD3+), B (CD19+), T‐helper (CD4+), T‐suppressor/cytotoxic (CD8+) cell counts and the CD4 to CD8 ratio in the growth retarded fetuses were significantly lower than the respective normal mean for gestation (CD3+: z = 3.66, P <0.001 ; CD19+: z = 2.18, P <0.05 ; CD4+: z = 3.76, P <0.001 ; CD8+: z = 2.26, P <0.05 ; and CD4/CD8: z = 2.27, P <0.05 ). There were significant associations between the decrease in the T lymphocyte subpopulations and the degree of fetal acidaemia. Conclusions Growth retarded fetuses demonstrate immune abnormalities that could be attributed to intrauterine starvation." @default.
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- W1973402376 date "1993-11-01" @default.
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- W1973402376 title "Fetal immunodeficiency: a consequence of placental insufficiency" @default.
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- W1973402376 doi "https://doi.org/10.1111/j.1471-0528.1993.tb15141.x" @default.
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