Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973403925> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1973403925 endingPage "1668" @default.
- W1973403925 startingPage "1661" @default.
- W1973403925 abstract "S. Lu and A. Hoey. Age- and Sex-associated Changes in Cardiac β1-adrenoceptors from the Muscular Dystrophy (mdx) Mice. Journal of Molecular and Cellular Cardiology (2000) 32, 1661–1668. Variations in β1-adrenoceptor function due to age or sex were examined in the mouse model of Duchenne muscular dystrophy. Positive chronotropic and inotropic responses to (-)-isoprenaline and antagonist effects of CGP20712A were determined in isolated right and left atria from young (12 week) and old (12 month) male and old (12 month) female mdx mice and their age- and sex-matched C57BL/10ScSn (C57) mice. There was no difference in efficacy to (-)-isoprenaline when expressed as an increase in the rate of contraction or force of contraction as a percentage of Ca2+-induced increase respectively in right or left atria from age- and sex-matched mdx and C57. Old mdx males showed a decreased sensitivity to (-)-isoprenaline (P<0.05) and a reduced affinity to CGP 20712A (P<0.05) in both right and left atria compared with old C57 males. These same changes were also observed in left atria between old and young mdx males. A reduced efficacy to (-)-isoprenaline was also evident when young and old mdx males were compared. In contrast, in old females, mdx showed an increased affinity to CGP20712A in left and right atria (P<0.05), and an enhanced sensitivity to (-)-isoprenaline in right atria. Finally, in left atria, the maximum Ca2+-induced increase in force of contraction was lower in all mdx compared to their age- and sex-matched C57 (P<0.05). In conclusion, age- and sex-associated changes inβ1 -adrenoceptor function and responses to calcium were demonstrated in cardiac muscle from mdx mice, with a marked deterioration in β1-adrenoceptor function occurring with aging in male mdx being particularly evident." @default.
- W1973403925 created "2016-06-24" @default.
- W1973403925 creator A5045734819 @default.
- W1973403925 creator A5045946565 @default.
- W1973403925 date "2000-09-01" @default.
- W1973403925 modified "2023-09-23" @default.
- W1973403925 title "Age- and Sex-associated Changes in Cardiac β1-adrenoceptors from the Muscular Dystrophy (mdx) Mouse" @default.
- W1973403925 cites W1506425163 @default.
- W1973403925 cites W1963532383 @default.
- W1973403925 cites W1968708631 @default.
- W1973403925 cites W1979471792 @default.
- W1973403925 cites W1983507539 @default.
- W1973403925 cites W1989282030 @default.
- W1973403925 cites W2001497490 @default.
- W1973403925 cites W2016321640 @default.
- W1973403925 cites W2019586126 @default.
- W1973403925 cites W2034142165 @default.
- W1973403925 cites W2035423528 @default.
- W1973403925 cites W2039302465 @default.
- W1973403925 cites W2064374012 @default.
- W1973403925 cites W2070432253 @default.
- W1973403925 cites W2073934668 @default.
- W1973403925 cites W2074912238 @default.
- W1973403925 cites W2076738615 @default.
- W1973403925 cites W2078666430 @default.
- W1973403925 cites W2094763401 @default.
- W1973403925 cites W2143475067 @default.
- W1973403925 cites W2161118746 @default.
- W1973403925 cites W2161233221 @default.
- W1973403925 cites W2313838404 @default.
- W1973403925 doi "https://doi.org/10.1006/jmcc.2000.1200" @default.
- W1973403925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10966828" @default.
- W1973403925 hasPublicationYear "2000" @default.
- W1973403925 type Work @default.
- W1973403925 sameAs 1973403925 @default.
- W1973403925 citedByCount "15" @default.
- W1973403925 countsByYear W19734039252014 @default.
- W1973403925 countsByYear W19734039252018 @default.
- W1973403925 countsByYear W19734039252021 @default.
- W1973403925 crossrefType "journal-article" @default.
- W1973403925 hasAuthorship W1973403925A5045734819 @default.
- W1973403925 hasAuthorship W1973403925A5045946565 @default.
- W1973403925 hasConcept C126322002 @default.
- W1973403925 hasConcept C134018914 @default.
- W1973403925 hasConcept C155710745 @default.
- W1973403925 hasConcept C158328960 @default.
- W1973403925 hasConcept C163415756 @default.
- W1973403925 hasConcept C170493617 @default.
- W1973403925 hasConcept C205545832 @default.
- W1973403925 hasConcept C24998067 @default.
- W1973403925 hasConcept C2776090920 @default.
- W1973403925 hasConcept C2776885963 @default.
- W1973403925 hasConcept C2777953023 @default.
- W1973403925 hasConcept C2778750056 @default.
- W1973403925 hasConcept C2778943923 @default.
- W1973403925 hasConcept C2779030066 @default.
- W1973403925 hasConcept C2780394045 @default.
- W1973403925 hasConcept C71924100 @default.
- W1973403925 hasConcept C84393581 @default.
- W1973403925 hasConceptScore W1973403925C126322002 @default.
- W1973403925 hasConceptScore W1973403925C134018914 @default.
- W1973403925 hasConceptScore W1973403925C155710745 @default.
- W1973403925 hasConceptScore W1973403925C158328960 @default.
- W1973403925 hasConceptScore W1973403925C163415756 @default.
- W1973403925 hasConceptScore W1973403925C170493617 @default.
- W1973403925 hasConceptScore W1973403925C205545832 @default.
- W1973403925 hasConceptScore W1973403925C24998067 @default.
- W1973403925 hasConceptScore W1973403925C2776090920 @default.
- W1973403925 hasConceptScore W1973403925C2776885963 @default.
- W1973403925 hasConceptScore W1973403925C2777953023 @default.
- W1973403925 hasConceptScore W1973403925C2778750056 @default.
- W1973403925 hasConceptScore W1973403925C2778943923 @default.
- W1973403925 hasConceptScore W1973403925C2779030066 @default.
- W1973403925 hasConceptScore W1973403925C2780394045 @default.
- W1973403925 hasConceptScore W1973403925C71924100 @default.
- W1973403925 hasConceptScore W1973403925C84393581 @default.
- W1973403925 hasIssue "9" @default.
- W1973403925 hasLocation W19734039251 @default.
- W1973403925 hasLocation W19734039252 @default.
- W1973403925 hasOpenAccess W1973403925 @default.
- W1973403925 hasPrimaryLocation W19734039251 @default.
- W1973403925 hasRelatedWork W1966957431 @default.
- W1973403925 hasRelatedWork W1973403925 @default.
- W1973403925 hasRelatedWork W2007938027 @default.
- W1973403925 hasRelatedWork W2008969240 @default.
- W1973403925 hasRelatedWork W2014480479 @default.
- W1973403925 hasRelatedWork W2044595397 @default.
- W1973403925 hasRelatedWork W2049828404 @default.
- W1973403925 hasRelatedWork W2069302378 @default.
- W1973403925 hasRelatedWork W2413535717 @default.
- W1973403925 hasRelatedWork W2077109392 @default.
- W1973403925 hasVolume "32" @default.
- W1973403925 isParatext "false" @default.
- W1973403925 isRetracted "false" @default.
- W1973403925 magId "1973403925" @default.
- W1973403925 workType "article" @default.