Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973409069> ?p ?o ?g. }
- W1973409069 endingPage "305" @default.
- W1973409069 startingPage "299" @default.
- W1973409069 abstract "β-Catenin is an evolutionally conserved protein which orchestrates myriad biological processes by regulating Wnt signaling and cell adhesion. The importance of the dual roles of β-catenin protein (signaling and structural) is highlighted throughout the development and adult life of all metazoan animals. β-Catenin is located in the cadherin-based adherent junctions in the plasma membrane of epithelial cells; upon Wnt activation, it accumulates and translocates to the nucleus in order to activate transcription. Thus, mutations in β-catenin and the components of the Wnt signal transduction pathway underline the aberrant activation of Wnt/β-catenin signaling in human diseases and cancers. In this review, we briefly summarize the core functions of β-catenin relevant to Wnt signaling and adhesion and introduce the additional and novel role of β-catenin related to the regulation of RiboNucleoAcid (RNA) metabolism. Such multiple functions of β-catenin can be understood by examining its structure and complex with the plethora of interacting proteins. Also, molecular evolution analysis has been used to understand the origin of multifunctionality of β-catenin. We will also discuss the newly identified role of β-catenin as an RNA-binding protein and as a regulator of RNA stability and splicing. It is hoped that future research will shed light on any unexpected findings by clarifying the RNA-mediated mechanism of β-catenin and the implication to Wnt-regulated pathogenesis." @default.
- W1973409069 created "2016-06-24" @default.
- W1973409069 creator A5062812749 @default.
- W1973409069 creator A5068376728 @default.
- W1973409069 date "2013-10-01" @default.
- W1973409069 modified "2023-09-27" @default.
- W1973409069 title "Multitasking β-catenin: from adhesion and transcription to RNA regulation" @default.
- W1973409069 cites W153332747 @default.
- W1973409069 cites W1533463539 @default.
- W1973409069 cites W1536067283 @default.
- W1973409069 cites W1858233634 @default.
- W1973409069 cites W1923089477 @default.
- W1973409069 cites W1958512987 @default.
- W1973409069 cites W1967113071 @default.
- W1973409069 cites W1973992999 @default.
- W1973409069 cites W1975993620 @default.
- W1973409069 cites W1981184799 @default.
- W1973409069 cites W1986818022 @default.
- W1973409069 cites W1988658871 @default.
- W1973409069 cites W1989215255 @default.
- W1973409069 cites W1998551458 @default.
- W1973409069 cites W2004350008 @default.
- W1973409069 cites W2006419043 @default.
- W1973409069 cites W2011172287 @default.
- W1973409069 cites W2013394636 @default.
- W1973409069 cites W2014748872 @default.
- W1973409069 cites W2015175027 @default.
- W1973409069 cites W2027864149 @default.
- W1973409069 cites W2035325399 @default.
- W1973409069 cites W2036999913 @default.
- W1973409069 cites W2040942754 @default.
- W1973409069 cites W2044359179 @default.
- W1973409069 cites W2050126707 @default.
- W1973409069 cites W2051604556 @default.
- W1973409069 cites W2059813946 @default.
- W1973409069 cites W2064027874 @default.
- W1973409069 cites W2065809107 @default.
- W1973409069 cites W2066379001 @default.
- W1973409069 cites W2082668329 @default.
- W1973409069 cites W2083903697 @default.
- W1973409069 cites W2083905520 @default.
- W1973409069 cites W2086964845 @default.
- W1973409069 cites W2090522288 @default.
- W1973409069 cites W2100070586 @default.
- W1973409069 cites W2102512718 @default.
- W1973409069 cites W2106531363 @default.
- W1973409069 cites W2107648723 @default.
- W1973409069 cites W2109955944 @default.
- W1973409069 cites W2112763851 @default.
- W1973409069 cites W2116315632 @default.
- W1973409069 cites W2122991629 @default.
- W1973409069 cites W2129336855 @default.
- W1973409069 cites W2130837149 @default.
- W1973409069 cites W2135555050 @default.
- W1973409069 cites W2142789997 @default.
- W1973409069 cites W2144796426 @default.
- W1973409069 cites W2144876726 @default.
- W1973409069 cites W2146311551 @default.
- W1973409069 cites W2146472503 @default.
- W1973409069 cites W2150171625 @default.
- W1973409069 cites W2154730918 @default.
- W1973409069 cites W2156227587 @default.
- W1973409069 cites W2158021558 @default.
- W1973409069 cites W2165781463 @default.
- W1973409069 cites W2166045997 @default.
- W1973409069 cites W2169960781 @default.
- W1973409069 doi "https://doi.org/10.1080/19768354.2013.853694" @default.
- W1973409069 hasPublicationYear "2013" @default.
- W1973409069 type Work @default.
- W1973409069 sameAs 1973409069 @default.
- W1973409069 citedByCount "4" @default.
- W1973409069 countsByYear W19734090692018 @default.
- W1973409069 countsByYear W19734090692020 @default.
- W1973409069 countsByYear W19734090692021 @default.
- W1973409069 crossrefType "journal-article" @default.
- W1973409069 hasAuthorship W1973409069A5062812749 @default.
- W1973409069 hasAuthorship W1973409069A5068376728 @default.
- W1973409069 hasBestOaLocation W19734090691 @default.
- W1973409069 hasConcept C104317684 @default.
- W1973409069 hasConcept C137620995 @default.
- W1973409069 hasConcept C138885662 @default.
- W1973409069 hasConcept C1491633281 @default.
- W1973409069 hasConcept C179926584 @default.
- W1973409069 hasConcept C194583182 @default.
- W1973409069 hasConcept C2779324961 @default.
- W1973409069 hasConcept C30145163 @default.
- W1973409069 hasConcept C41282012 @default.
- W1973409069 hasConcept C41895202 @default.
- W1973409069 hasConcept C53345823 @default.
- W1973409069 hasConcept C54355233 @default.
- W1973409069 hasConcept C54458228 @default.
- W1973409069 hasConcept C62478195 @default.
- W1973409069 hasConcept C67705224 @default.
- W1973409069 hasConcept C85789140 @default.
- W1973409069 hasConcept C86339819 @default.
- W1973409069 hasConcept C86803240 @default.
- W1973409069 hasConcept C95444343 @default.
- W1973409069 hasConceptScore W1973409069C104317684 @default.