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• W1973411232 endingPage "465" @default.
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• W1973411232 abstract "Fourier transform infrared (FT-IR) spectra of deoxyribonucleic acid (DNA) and its reaction products with the anticancer drug cis-Pt(NH 3 ) 2 Cl 2 , cis-diamminodichloroplatinum (abbreviated cisplatin) in water and heavy water solutions or gels have been obtained and studied. The mid-IR spectra show considerable changes in the carbonyl (C=0) region and weaker, but significant perturbations in the sugar-phosphate absorption region (PO 2 − , OPC and COP). The carbonyl bands at 1710 and 1686 cm −1 of the control DNA in H 2 O and D 2 O, respectively, disappear and shift to lower frequencies in the spectra of cisplatin + DNA with a r = Pt/P = 0.2. Furthermore, the sugar-phosphate band at 1054 cm −1 of the C—O stretching vibration of the ribose-phosphate bond is reduced in intensity and slightly shifted to higher frequencies, indicating a reorientation of the phosphate group. In addition, the P—O stretching vibration frequency at 970 cm −1 is reduced in intensity on interaction with the drug. These changes depend to some extent on the water content in the control DNA and in the cisplatin + DNA complex. The water molecules in DNA in the presence of cisplatin reorganize themselves. The attack of the platinum drug at the N 7 site of the guanine molecule in DNA exerts an effect on the DNA structure through a modification of the water average configuration and its stabilizing effect on the secondary structure." @default.
• W1973411232 created "2016-06-24" @default.
• W1973411232 creator A5000390110 @default.
• W1973411232 date "1981-09-01" @default.
• W1973411232 modified "2023-10-08" @default.
• W1973411232 title "Fourier Transform Infrared Spectra of Calf Thymus DNA and its Reactions with the Anticancer Drug Cisplatin" @default.
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• W1973411232 doi "https://doi.org/10.1366/0003702814732274" @default.
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