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• W1973414360 endingPage "865" @default.
• W1973414360 startingPage "860" @default.
• W1973414360 abstract "Mitochondrial DNA polymerase from Drosophila embryos has been characterized with regard to its mechanism of DNA synthesis in the presence of single-stranded DNA-binding protein from Escherichia coli. The rate of DNA synthesis by DNA polymerase γ was increased nearly 40-fold upon addition of single-stranded DNA-binding protein. Processivity of mitochondrial DNA polymerase was increased ∼ 2-fold, while its intrinsic rate of nucleotide polymerization was unaffected. Primer extension analysis showed that the rate of initiation of DNA strand synthesis by DNA polymerase γ was increased 25-fold in the presence of single-stranded DNA-binding protein. Our results indicate that the stimulation of Drosophila DNA polymerase γ by single-stranded DNA-binding protein results primarily from an increased rate of primer recognition and binding. Concurrent achievement of maximal activity and processivity by mitochondrial DNA polymerase in the presence of binding protein suggests that DNA polymerase γ , like other replicative DNA polymerases, associates with accessory factors in vivo to catalyze efficient and processive DNA synthesis. Mitochondrial DNA polymerase from Drosophila embryos has been characterized with regard to its mechanism of DNA synthesis in the presence of single-stranded DNA-binding protein from Escherichia coli. The rate of DNA synthesis by DNA polymerase γ was increased nearly 40-fold upon addition of single-stranded DNA-binding protein. Processivity of mitochondrial DNA polymerase was increased ∼ 2-fold, while its intrinsic rate of nucleotide polymerization was unaffected. Primer extension analysis showed that the rate of initiation of DNA strand synthesis by DNA polymerase γ was increased 25-fold in the presence of single-stranded DNA-binding protein. Our results indicate that the stimulation of Drosophila DNA polymerase γ by single-stranded DNA-binding protein results primarily from an increased rate of primer recognition and binding. Concurrent achievement of maximal activity and processivity by mitochondrial DNA polymerase in the presence of binding protein suggests that DNA polymerase γ , like other replicative DNA polymerases, associates with accessory factors in vivo to catalyze efficient and processive DNA synthesis." @default.
• W1973414360 created "2016-06-24" @default.
• W1973414360 creator A5003110791 @default.
• W1973414360 creator A5075116498 @default.
• W1973414360 date "1995-01-01" @default.
• W1973414360 modified "2023-09-30" @default.
• W1973414360 title "Stimulation of Drosophila Mitochondrial DNA Polymerase by Single-stranded DNA-binding Protein" @default.
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• W1973414360 doi "https://doi.org/10.1074/jbc.270.2.860" @default.
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