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- W1973417247 abstract "To investigate the role of p27 in the inhibition of emodin on the mesangial cell (MC) proliferation induced by tumor necrosis factor-alpha(TNF-alpha).p27 protein of MC was detected with western blotting analysis. The degree of MC proliferation was estimated through [(3)H] thymidine ([(3)H] TdR) incorporation. Different dosage of emodin (50 mg/L,100 mg/L) was added into MC stimulated by TNF-alpha.TNF-alpha (200 kU/L) decreased p27 level of MC cultured in serum-free DMEM for 24 hours and increased[(3)H] TdR incorporation. Emodin increased p27 level of MC stimulated by TNF-alpha and decreased [(3)H] TdR incorporation. The more the emodin was added, the greater the above-mentioned effect of emodin.The increment of p27 level maybe play an important role in the inhibition of emodin on MC proliferation induced by TNF-alpha." @default.
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- W1973417247 date "2004-03-15" @default.
- W1973417247 modified "2023-09-27" @default.
- W1973417247 title "Role of cyclin kinase inhibitor p27 in inhibition of emodin on mesangial cell proliferation induced by tumor necrosis factor-α" @default.
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- W1973417247 doi "https://doi.org/10.3736/jcim20040213" @default.
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