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• W1973428087 abstract "SUMMARY Human intraepithelial lymphocytes (IEL), CD8+ lymphocytes located between epithelial cells, are likely to be influenced by the immunosuppressive cytokine, TGF-β, secreted by epithelial cells. This study evaluates the effects of TGF-β on IEL functions. IEL were derived from proximal jejunum of patients undergoing gastric bypass operations for morbid obesity. Proliferation was determined by 3H-thymidine incorporation; IL-2 production, by ELISA; expression of IL-2 receptor, CD2, HML1, CD16, and CD56, by immunofluorescence; binding, by adherence of radiolabelled cells; and cytotoxicity by 51Cr-release assay. TGF-β (≥ 1 ng/ml) inhibited the mitosis of IEL to mitogens, IL-7, and stimuli of the CD2 and CD3 pathways. The blocking effect did not target the activation events of IL-2 production and receptor generation. Rather, it reduced cell division after activation when added 24 h after initiating the culture. Antibody neutralization of naturally occurring TGF-β increased IEL proliferation to IL-2, but not to the other stimuli. Of the multiple surface markers tested, only CD2 and HML1 expression increased with TGF-β and decreased with antibody to TGF-β, although the cytokine and the neutralizing antibody had no effects on IEL binding to colon cancer. TGF-β reduced the number of CD56+ IEL and the lymphokine-activated killing when co-cultured with IL-7 but not with IL-2 or IL-15. TGF-β inhibits certain IEL functions: the reduction in cell division rather than activation and a decline in IL-7-mediated lysis of colon cancer due to a lowering of the number of natural killer cells." @default.
• W1973428087 created "2016-06-24" @default.
• W1973428087 creator A5025377112 @default.
• W1973428087 date "1999-03-01" @default.
• W1973428087 modified "2023-10-12" @default.
• W1973428087 title "Inhibitory effects of transforming growth factor-beta (TGF-β) on certain functions of intraepithelial lymphocytes" @default.
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• W1973428087 doi "https://doi.org/10.1046/j.1365-2249.1999.00824.x" @default.
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