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- W1973430897 abstract "The Ca2+ chelators, EGTA and BAPTA, have been introduced into intact, isolated rat pancreatic acini using a hypotonic swelling method. This resulted in complete inhibition of amylase release, stimulated by carbamylcholine at a submaximal concentration and 82–85% inhibition at maximal concentrations. Acini swollen in the absence of Ca2+ chelators showed similar secretory responses to those of unswollen acini. Treatment of unswollen acini with chelators inhibited the maximum reponse to carbamylcholine by only 23%. The inhibitory effect of intracellular chelators was not due to ATP depletion or a lowering of the total cell Ca2+ content. Thus, these results provide the first direct demonstration that an increase in intracellular Ca2+ concentration is necessary for the stimulation of enzyme release from pancreatic acinar cells." @default.
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- W1973430897 date "1984-03-01" @default.
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- W1973430897 title "Introduction of calcium chelators into isolated rat pancreatic acini inhibits amylase release in response to carbamylcholine" @default.
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- W1973430897 doi "https://doi.org/10.1016/0006-291x(84)90855-6" @default.
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