FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973435986> ?p ?o ?g. }

• W1973435986 abstract "This research investigated the feasibility of using time-dependent diffuse reflectance spectroscopy to differentiatepediatric epileptic brain tissue from normal brain tissue. The optical spectroscopic technique monitored the dynamicoptical properties of the cerebral cortex that are associated with its physiological, morphological, and compositionalcharacteristics. Due to the transient irregular epileptic discharge activity within the epileptic brain tissue it washypothesized that the lesion would express abnormal dynamic optical behavior that would alter normal dynamicbehavior. Thirteen pediatric epilepsy patients and seven pediatric brain tumor patients (normal controls) were recruitedfor this clinical study. Dynamic optical properties were obtained from the cortical surface intraoperatively using a timedependentdiffuse reflectance spectroscopy system. This system consisted of a fiber-optic probe, a tungsten-halogen lightsource, and a spectrophotometer. It acquired diffuse reflectance spectra with a spectral range of 204 nm to 932 nm at arate of 33 spectra per second for approximately 12 seconds. Biopsy samples were taken from electrophysiologicallyabnormal cortex and evaluated by a neuropathologist, which served as a gold standard for lesion classification. For dataanalysis, spectral intensity changes of diffuse reflectance in the time domain at two different wavelengths from eachinvestigated site were compared. Negative correlation segment, defined by the periods where the intensity changes at thetwo wavelengths were opposite in their slope polarity, were extracted. The total duration of correlation, referredto as the negative correlation time index, was calculated by integrating the correlation segments. The negativecorrelation time indices from all investigated sites were sub-grouped according to the corresponding histologicalclassifications. The difference between the mean indices of two subgroups was evaluated by standard t-test. Thesecomparison and calculation procedures were carried out for all possible wavelength combinations between 400 nm and800 nm with 2 nm increments. The positive group consisted of seven pathologically abnormal test sites, and the negativegroup consisted of 13 normal test sites from non-epileptic tumor patients. A standard t-test showed significant differencebetween correlation time indices from the two groups at the wavelength combinations of 700-760 nm versus550-580 nm. An empirical discrimination algorithm based on the correlation time indices in this range produced100% sensitivity and 85% specificity. Based on these results time-dependent diffuse reflectance spectroscopy withoptimized data analysis methods differentiates epileptic brain tissue from normal brain tissue adequately, therefore canbe utilized for surgical guidance, and may enhance the surgical outcome of pediatric epilepsy surgery." @default.
• W1973435986 created "2016-06-24" @default.
• W1973435986 creator A5002457801 @default.
• W1973435986 creator A5004861040 @default.
• W1973435986 creator A5015150415 @default.
• W1973435986 creator A5021387161 @default.
• W1973435986 creator A5023712884 @default.
• W1973435986 creator A5026946127 @default.
• W1973435986 creator A5085150194 @default.
• W1973435986 date "2009-05-01" @default.
• W1973435986 modified "2023-09-23" @default.
• W1973435986 title "Differentiating pediatric epileptic brain tissue from normal brain tissue by using time-dependent diffuse reflectance spectroscopy in vivo: comprehensive data analysis method in the time domain" @default.
• W1973435986 doi "https://doi.org/10.1117/12.818767" @default.
• W1973435986 hasPublicationYear "2009" @default.
• W1973435986 type Work @default.
• W1973435986 sameAs 1973435986 @default.
• W1973435986 citedByCount "0" @default.
• W1973435986 crossrefType "proceedings-article" @default.
• W1973435986 hasAuthorship W1973435986A5002457801 @default.
• W1973435986 hasAuthorship W1973435986A5004861040 @default.
• W1973435986 hasAuthorship W1973435986A5015150415 @default.
• W1973435986 hasAuthorship W1973435986A5021387161 @default.
• W1973435986 hasAuthorship W1973435986A5023712884 @default.
• W1973435986 hasAuthorship W1973435986A5026946127 @default.
• W1973435986 hasAuthorship W1973435986A5085150194 @default.
• W1973435986 hasConcept C120665830 @default.
• W1973435986 hasConcept C121332964 @default.
• W1973435986 hasConcept C142724271 @default.
• W1973435986 hasConcept C156328458 @default.
• W1973435986 hasConcept C161790260 @default.
• W1973435986 hasConcept C185592680 @default.
• W1973435986 hasConcept C192562407 @default.
• W1973435986 hasConcept C2779130545 @default.
• W1973435986 hasConcept C2781156865 @default.
• W1973435986 hasConcept C2989005 @default.
• W1973435986 hasConcept C32891209 @default.
• W1973435986 hasConcept C46141821 @default.
• W1973435986 hasConcept C55493867 @default.
• W1973435986 hasConcept C62520636 @default.
• W1973435986 hasConcept C65165184 @default.
• W1973435986 hasConcept C71924100 @default.
• W1973435986 hasConcept C82261727 @default.
• W1973435986 hasConceptScore W1973435986C120665830 @default.
• W1973435986 hasConceptScore W1973435986C121332964 @default.
• W1973435986 hasConceptScore W1973435986C142724271 @default.
• W1973435986 hasConceptScore W1973435986C156328458 @default.
• W1973435986 hasConceptScore W1973435986C161790260 @default.
• W1973435986 hasConceptScore W1973435986C185592680 @default.
• W1973435986 hasConceptScore W1973435986C192562407 @default.
• W1973435986 hasConceptScore W1973435986C2779130545 @default.
• W1973435986 hasConceptScore W1973435986C2781156865 @default.
• W1973435986 hasConceptScore W1973435986C2989005 @default.
• W1973435986 hasConceptScore W1973435986C32891209 @default.
• W1973435986 hasConceptScore W1973435986C46141821 @default.
• W1973435986 hasConceptScore W1973435986C55493867 @default.
• W1973435986 hasConceptScore W1973435986C62520636 @default.
• W1973435986 hasConceptScore W1973435986C65165184 @default.
• W1973435986 hasConceptScore W1973435986C71924100 @default.
• W1973435986 hasConceptScore W1973435986C82261727 @default.
• W1973435986 hasLocation W19734359861 @default.
• W1973435986 hasOpenAccess W1973435986 @default.
• W1973435986 hasPrimaryLocation W19734359861 @default.
• W1973435986 hasRelatedWork W1978064760 @default.
• W1973435986 hasRelatedWork W2079944389 @default.
• W1973435986 hasRelatedWork W2083143568 @default.
• W1973435986 hasRelatedWork W2091460820 @default.
• W1973435986 hasRelatedWork W2150160562 @default.
• W1973435986 hasRelatedWork W2212767772 @default.
• W1973435986 hasRelatedWork W2388787978 @default.
• W1973435986 hasRelatedWork W2575469826 @default.
• W1973435986 hasRelatedWork W2803387716 @default.
• W1973435986 hasRelatedWork W2953613308 @default.
• W1973435986 isParatext "false" @default.
• W1973435986 isRetracted "false" @default.
• W1973435986 magId "1973435986" @default.
• W1973435986 workType "article" @default.