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• W1973436974 endingPage "102" @default.
• W1973436974 startingPage "93" @default.
• W1973436974 abstract "Research during the past two decades supports a complex role for neuropeptide tyrosine (NPY) and two of its associated receptors, the Y1 receptor and the Y2 receptor, in the modulation of pain, in addition to regeneration and survival mechanisms at the spinal level. Thus, NPY has been shown to both cause and reduce pain, in addition to having biphasic effects. Recent research has focused on the distribution of the spinal NPY-mediated system. Here, we propose various possible scenarios for the role of NPY in pain processing, based on its actions at different sites (axon versus cell body), through different receptors (Y1 receptor versus Y2 receptor) and/or types of neuron (ganglion neurons and intraganglionic cross-excitation versus interneurons versus projection neurons). Research during the past two decades supports a complex role for neuropeptide tyrosine (NPY) and two of its associated receptors, the Y1 receptor and the Y2 receptor, in the modulation of pain, in addition to regeneration and survival mechanisms at the spinal level. Thus, NPY has been shown to both cause and reduce pain, in addition to having biphasic effects. Recent research has focused on the distribution of the spinal NPY-mediated system. Here, we propose various possible scenarios for the role of NPY in pain processing, based on its actions at different sites (axon versus cell body), through different receptors (Y1 receptor versus Y2 receptor) and/or types of neuron (ganglion neurons and intraganglionic cross-excitation versus interneurons versus projection neurons). DRG neurons might be divided, among others, into A- and C-type neurons. A-neurons produce large myelinated axons and transmit tactile information, whereas C-neurons produce thin, unmyelinated axons often transmitting pain signals. complete transection of an axon or entire nerve. long axonal processes produced by (projection) neurons located in the spinal cord, running in the cranial direction and terminating in rostral spinal cord segments or brain. sensory ganglion containing pseudounipolar neurons of different sizes and located bilaterally along the vertebral column. The single primary axon of the pseudounipolar neuron bifurcates within the DRG, sending a process to the periphery to collect sensory information and a central branch, which relays that information to the spinal cord. endogenous peptides, which are ligands for some of the ‘morphine receptors’. the different populations of dorsal and ventral horn neurons are grouped in laminae, most easily identified in transverse sections of the spinal cord. Thus, ten laminae were identified in the cat spinal cord by the Swedísh neuroanatomist Bror Rexed in the early 1950s. a small, compact collection of neurons in the pons, adjacent to the fourth ventricle, virtually exclusively containing NA neurons. In the human brain, these neurons are bluish – therefore its name. the structures in which the distal ends of axons terminate. They primarily contact other nerve cells, and contain and release transmitters that, depending on the type, convey excitation or inhibition. injury of the axonal processes of neurons (includes axotomy, as well as many other types of lesions, e.g. nerve compression). cell bodies of neurons. the area of the gray matter containing a dense network of interwoven synaptic terminals, axons, dendrites and glial processes but lacking cell soma. receptors for messenger molecules in or on the cell body (or soma) of the neuron (in fact, also on glial cells). neurons in the gray matter of the dorsal and ventral horns. Neurons located in the dorsal horn are the primary targets for the central branches (or primary afferents) of sensory DRG neurons. pain emerging from the visceral organs. released messenger molecules diffuse over variable distances to reach the appropriate receptor(s). Sometimes called extrasynaptic or non-synaptic transmission." @default.
• W1973436974 created "2016-06-24" @default.
• W1973436974 creator A5043880888 @default.
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• W1973436974 creator A5077494149 @default.
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• W1973436974 creator A5081923678 @default.
• W1973436974 date "2007-02-01" @default.
• W1973436974 modified "2023-10-17" @default.
• W1973436974 title "Neuropeptide tyrosine and pain" @default.
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