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• W1973437342 startingPage "1175" @default.
• W1973437342 abstract "Twin pregnancies with a complete hydatidiform mole (CHM) and a coexisting fetus have an aggressive postevacuation behavior; it is, therefore, important to differentiate these cases from partial hydatidiform moles that rarely require treatment for late sequelae. It has been presumed that twin pregnancies with a CHM and a coexistent fetus are dizygotic gestations, but this has not been confirmed in most cases. The authors investigated the sex chromosomal constitution of paraffin-embedded, formalin-fixed placental tissues in nine pregnancies histopathologically diagnosed as twin gestations with CHM and coexisting fetus, using fluorescent in situ hybridization (FISH) with X- and Y-chromosomal probes. Normal placental tissues showed an even sex distribution—four cases: X signal only, presumably female; four cases: X and Y signals, presumably male. In contrast, all molar tissues of these same pregnancies hybridized with the Xchromosomal probe only. Thus, in four of nine cases, gender differences (ie, different sex chromosome content) in molar villi (X chromosome only, cytogenetic female) versus normal villi (both sex chromosomes, cytogenetic male) confirmed the histopathological diagnosis of dizygotic twinning; a strict relationship between villous morphology (molar vs normal) and chromosomal gender was observed in each instance. This study illustrates that use of FISH on paraffin-embedded tissues can retrospectively establish dizygotic twinning in this unusual type of molar gestation." @default.
• W1973437342 created "2016-06-24" @default.
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• W1973437342 date "1995-11-01" @default.
• W1973437342 modified "2023-10-17" @default.
• W1973437342 title "Twin pregnancies with complete hydatidiform mole and coexisting fetus: Use of fluorescent in situ hybridization to evaluate placental X- and Y-chromosomal content" @default.
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• W1973437342 doi "https://doi.org/10.1016/0046-8177(95)90189-2" @default.
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• W1973437342 hasPublicationYear "1995" @default.
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