Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973447498> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1973447498 endingPage "114" @default.
- W1973447498 startingPage "111" @default.
- W1973447498 abstract "Substance P is a member of the tachykinin family of neuropeptides that plays an important role in pain transmission, neurogenic inflammatory diseases and the adaptive response to stress. Substance P exerts its biological activities via binding to a G-protein coupled receptor of the neurokinin (NK) receptor family. Here, we show by Western blot experiments that substance P induced a transient synthesis of the zinc finger transcriptional regulator Egr-1 in human glioma cells. Substance P-induced stimulation of Egr-1 biosynthesis was completely inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 and by AG1487, an epidermal growth factor (EGF) receptor-specific tyrosine kinase inhibitor. These results indicate that transactivation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal-regulated protein kinase (ERK) are essential for substance P/NK-1 receptor-induced activation of Egr-1 biosynthesis. Moreover, we show that the signaling cascade initiated by substance P or EGF are indistinguishable, including the activation of the EGF receptor, the activation of ERK, and the final stimulation of Egr-1 biosynthesis. The synthesis of Egr-1 in glioma cells as a result of substance P stimulation suggests that substance P exerts long-term effects in glioma cells via Egr-1-mediated gene transcription." @default.
- W1973447498 created "2016-06-24" @default.
- W1973447498 creator A5007731282 @default.
- W1973447498 creator A5077237302 @default.
- W1973447498 date "2002-10-01" @default.
- W1973447498 modified "2023-09-23" @default.
- W1973447498 title "Substance P induced biosynthesis of the zinc finger transcription factor Egr-1 in human glioma cells requires activation of the epidermal growth factor receptor and of extracellular signal-regulated protein kinase" @default.
- W1973447498 cites W1490481380 @default.
- W1973447498 cites W1567881416 @default.
- W1973447498 cites W1650183152 @default.
- W1973447498 cites W1821495885 @default.
- W1973447498 cites W1971915141 @default.
- W1973447498 cites W1979380946 @default.
- W1973447498 cites W1980669305 @default.
- W1973447498 cites W2004799627 @default.
- W1973447498 cites W2020835847 @default.
- W1973447498 cites W2024375726 @default.
- W1973447498 cites W2032995938 @default.
- W1973447498 cites W2033926730 @default.
- W1973447498 cites W2036553065 @default.
- W1973447498 cites W2058096933 @default.
- W1973447498 cites W2090105988 @default.
- W1973447498 cites W2112466568 @default.
- W1973447498 cites W2167604659 @default.
- W1973447498 doi "https://doi.org/10.1016/s0304-3940(02)00939-4" @default.
- W1973447498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12384223" @default.
- W1973447498 hasPublicationYear "2002" @default.
- W1973447498 type Work @default.
- W1973447498 sameAs 1973447498 @default.
- W1973447498 citedByCount "19" @default.
- W1973447498 countsByYear W19734474982013 @default.
- W1973447498 countsByYear W19734474982014 @default.
- W1973447498 countsByYear W19734474982016 @default.
- W1973447498 countsByYear W19734474982017 @default.
- W1973447498 countsByYear W19734474982019 @default.
- W1973447498 crossrefType "journal-article" @default.
- W1973447498 hasAuthorship W1973447498A5007731282 @default.
- W1973447498 hasAuthorship W1973447498A5077237302 @default.
- W1973447498 hasConcept C104317684 @default.
- W1973447498 hasConcept C118303440 @default.
- W1973447498 hasConcept C1292079 @default.
- W1973447498 hasConcept C170493617 @default.
- W1973447498 hasConcept C180361614 @default.
- W1973447498 hasConcept C185592680 @default.
- W1973447498 hasConcept C2775960820 @default.
- W1973447498 hasConcept C2776362946 @default.
- W1973447498 hasConcept C2776533618 @default.
- W1973447498 hasConcept C42362537 @default.
- W1973447498 hasConcept C502942594 @default.
- W1973447498 hasConcept C55493867 @default.
- W1973447498 hasConcept C57074206 @default.
- W1973447498 hasConcept C62478195 @default.
- W1973447498 hasConcept C79186569 @default.
- W1973447498 hasConcept C86339819 @default.
- W1973447498 hasConcept C86803240 @default.
- W1973447498 hasConcept C95444343 @default.
- W1973447498 hasConceptScore W1973447498C104317684 @default.
- W1973447498 hasConceptScore W1973447498C118303440 @default.
- W1973447498 hasConceptScore W1973447498C1292079 @default.
- W1973447498 hasConceptScore W1973447498C170493617 @default.
- W1973447498 hasConceptScore W1973447498C180361614 @default.
- W1973447498 hasConceptScore W1973447498C185592680 @default.
- W1973447498 hasConceptScore W1973447498C2775960820 @default.
- W1973447498 hasConceptScore W1973447498C2776362946 @default.
- W1973447498 hasConceptScore W1973447498C2776533618 @default.
- W1973447498 hasConceptScore W1973447498C42362537 @default.
- W1973447498 hasConceptScore W1973447498C502942594 @default.
- W1973447498 hasConceptScore W1973447498C55493867 @default.
- W1973447498 hasConceptScore W1973447498C57074206 @default.
- W1973447498 hasConceptScore W1973447498C62478195 @default.
- W1973447498 hasConceptScore W1973447498C79186569 @default.
- W1973447498 hasConceptScore W1973447498C86339819 @default.
- W1973447498 hasConceptScore W1973447498C86803240 @default.
- W1973447498 hasConceptScore W1973447498C95444343 @default.
- W1973447498 hasIssue "2" @default.
- W1973447498 hasLocation W19734474981 @default.
- W1973447498 hasLocation W19734474982 @default.
- W1973447498 hasOpenAccess W1973447498 @default.
- W1973447498 hasPrimaryLocation W19734474981 @default.
- W1973447498 hasRelatedWork W1978760124 @default.
- W1973447498 hasRelatedWork W2004726042 @default.
- W1973447498 hasRelatedWork W2041096852 @default.
- W1973447498 hasRelatedWork W2041467949 @default.
- W1973447498 hasRelatedWork W2131071424 @default.
- W1973447498 hasRelatedWork W2381340599 @default.
- W1973447498 hasRelatedWork W2462039273 @default.
- W1973447498 hasRelatedWork W2885767093 @default.
- W1973447498 hasRelatedWork W3161529354 @default.
- W1973447498 hasRelatedWork W4385758414 @default.
- W1973447498 hasVolume "332" @default.
- W1973447498 isParatext "false" @default.
- W1973447498 isRetracted "false" @default.
- W1973447498 magId "1973447498" @default.
- W1973447498 workType "article" @default.