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• W1973449115 abstract "The effects of Cu2+, Fe2+ and Zn2+ on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex were examined. Cu2+ and Zn2+ (0.05-0.5 mM) inhibited the activity of this enzyme in a dose-dependent manner. The concentration required for 50% inhibition was approximately 0.1 mM for Cu2+ and 0.15 mM for Zn2+. The inhibition by both metals was uncompetitive and non-competitive with regard to NAD+ and prostaglandin E2, respectively, indicating that the mechanisms of the inhibition on the enzyme of both metals may be the same. Fe2+ had no effect on the activity of this enzyme. These results suggest that Cu2+ and Zn2+ have the potential to modulate the catabolism of prostaglandins by the kidney cortex." @default.
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• W1973449115 date "1990-11-01" @default.
• W1973449115 modified "2023-10-16" @default.
• W1973449115 title "Effects of metal ions on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex" @default.
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• W1973449115 doi "https://doi.org/10.1016/0090-6980(90)90112-9" @default.
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