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• W1973453952 abstract "The purpose of this study was to determine the effect of dietary supplementation with the anti-inflammatory compound resveratrol in pregnant dams on lipopolysaccharide (LPS)-induced dopaminergic deficits in pups exposed to LPS in utero. Gravid female rats were fed with a resveratrol-enriched diet during gestational days 3–22.5 (E3–E22.5) and received an intraperitoneal (i.p.) injection of 1 mg/kg LPS at E10.5. The striata were isolated from the pups at postnatal days 10 (P10) and P21. LPS-induced dopaminergic deficits were noted at P21, but not P10. These DA deficits at P21 were exhibited by a loss of DA and DA metabolite [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] levels and tyrosine hydroxylase (TH) expression in the striatum. The LPS-induced loss of DA, DA metabolites, and TH expression were attenuated in the striata of pups from the dams fed with the resveratrol-supplemented diet. These data suggest that a resveratrol-supplemented diet may restore homeostasis of the striatal DA neuronal system following disruption by LPS." @default.
• W1973453952 created "2016-06-24" @default.
• W1973453952 creator A5020539295 @default.
• W1973453952 creator A5026448193 @default.
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• W1973453952 date "2014-07-01" @default.
• W1973453952 modified "2023-10-17" @default.
• W1973453952 title "Dietary supplementation with resveratrol protects against striatal dopaminergic deficits produced by in utero LPS exposure" @default.
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• W1973453952 doi "https://doi.org/10.1016/j.brainres.2014.05.028" @default.
• W1973453952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24863468" @default.
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