FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973455669> ?p ?o ?g. }

• W1973455669 endingPage "2124" @default.
• W1973455669 startingPage "2112" @default.
• W1973455669 abstract "Background: Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobiology of periodontitis and would inform the design of future studies. Methods: Ninety systemically healthy non‐smokers with moderate to advanced periodontitis (63 with chronic periodontitis and 27 with aggressive periodontitis) each contributed at least two diseased interproximal papillae (with bleeding on probing [BOP], probing depth [PD] ≥4 mm, and attachment loss [AL] ≥3 mm) and a healthy papilla, if available (no BOP, PD ≤4 mm, and AL ≤2 mm). RNA was extracted, amplified, reverse‐transcribed, labeled, and hybridized with whole genome microarrays. Differential expression was assayed in 247 individual tissue samples (183 from diseased sites and 64 from healthy sites) using a standard mixed‐effects linear model approach, with patient effects considered random with a normal distribution and gingival tissue status considered a two‐level fixed effect. Gene ontology analysis classified the expression patterns into biologically relevant categories. Results: Transcriptome analysis revealed that 12,744 probe sets were differentially expressed after adjusting for multiple comparisons ( P <9.15 × 10 −7 ). Of those, 5,295 were upregulated and 7,449 were downregulated in disease compared to health. Gene ontology analysis identified 61 differentially expressed groups (adjusted P <0.05), including apoptosis, antimicrobial humoral response, antigen presentation, regulation of metabolic processes, signal transduction, and angiogenesis. Conclusion: Gingival tissue transcriptomes provide a valuable scientific tool for further hypothesis‐driven studies of the pathobiology of periodontitis." @default.
• W1973455669 created "2016-06-24" @default.
• W1973455669 creator A5012525044 @default.
• W1973455669 creator A5012991069 @default.
• W1973455669 creator A5019161561 @default.
• W1973455669 creator A5037772419 @default.
• W1973455669 creator A5039168176 @default.
• W1973455669 creator A5042615281 @default.
• W1973455669 creator A5045096408 @default.
• W1973455669 creator A5086415630 @default.
• W1973455669 date "2008-11-01" @default.
• W1973455669 modified "2023-10-16" @default.
• W1973455669 title "Transcriptomes in Healthy and Diseased Gingival Tissues" @default.
• W1973455669 cites W1544923801 @default.
• W1973455669 cites W1964895626 @default.
• W1973455669 cites W1966317579 @default.
• W1973455669 cites W1972363197 @default.
• W1973455669 cites W1973803938 @default.
• W1973455669 cites W1977813572 @default.
• W1973455669 cites W1978637623 @default.
• W1973455669 cites W1998026456 @default.
• W1973455669 cites W2008191147 @default.
• W1973455669 cites W2013080017 @default.
• W1973455669 cites W2020310744 @default.
• W1973455669 cites W2022300029 @default.
• W1973455669 cites W2024916880 @default.
• W1973455669 cites W2026546599 @default.
• W1973455669 cites W2032665956 @default.
• W1973455669 cites W2033854978 @default.
• W1973455669 cites W2035800961 @default.
• W1973455669 cites W2047928920 @default.
• W1973455669 cites W2074228092 @default.
• W1973455669 cites W2088258179 @default.
• W1973455669 cites W2090969569 @default.
• W1973455669 cites W2106503300 @default.
• W1973455669 cites W2106794374 @default.
• W1973455669 cites W2109799530 @default.
• W1973455669 cites W2109972881 @default.
• W1973455669 cites W2113493746 @default.
• W1973455669 cites W2134889157 @default.
• W1973455669 cites W2174784305 @default.
• W1973455669 cites W2183290494 @default.
• W1973455669 cites W2315456763 @default.
• W1973455669 cites W2473562090 @default.
• W1973455669 cites W275754419 @default.
• W1973455669 cites W4241225996 @default.
• W1973455669 cites W4249011053 @default.
• W1973455669 doi "https://doi.org/10.1902/jop.2008.080139" @default.
• W1973455669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2637651" @default.
• W1973455669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18980520" @default.
• W1973455669 hasPublicationYear "2008" @default.
• W1973455669 type Work @default.
• W1973455669 sameAs 1973455669 @default.
• W1973455669 citedByCount "155" @default.
• W1973455669 countsByYear W19734556692012 @default.
• W1973455669 countsByYear W19734556692013 @default.
• W1973455669 countsByYear W19734556692014 @default.
• W1973455669 countsByYear W19734556692015 @default.
• W1973455669 countsByYear W19734556692016 @default.
• W1973455669 countsByYear W19734556692017 @default.
• W1973455669 countsByYear W19734556692018 @default.
• W1973455669 countsByYear W19734556692019 @default.
• W1973455669 countsByYear W19734556692020 @default.
• W1973455669 countsByYear W19734556692021 @default.
• W1973455669 countsByYear W19734556692022 @default.
• W1973455669 countsByYear W19734556692023 @default.
• W1973455669 crossrefType "journal-article" @default.
• W1973455669 hasAuthorship W1973455669A5012525044 @default.
• W1973455669 hasAuthorship W1973455669A5012991069 @default.
• W1973455669 hasAuthorship W1973455669A5019161561 @default.
• W1973455669 hasAuthorship W1973455669A5037772419 @default.
• W1973455669 hasAuthorship W1973455669A5039168176 @default.
• W1973455669 hasAuthorship W1973455669A5042615281 @default.
• W1973455669 hasAuthorship W1973455669A5045096408 @default.
• W1973455669 hasAuthorship W1973455669A5086415630 @default.
• W1973455669 hasBestOaLocation W19734556692 @default.
• W1973455669 hasConcept C104317684 @default.
• W1973455669 hasConcept C126322002 @default.
• W1973455669 hasConcept C142724271 @default.
• W1973455669 hasConcept C150194340 @default.
• W1973455669 hasConcept C162317418 @default.
• W1973455669 hasConcept C186836561 @default.
• W1973455669 hasConcept C2777968807 @default.
• W1973455669 hasConcept C2779337755 @default.
• W1973455669 hasConcept C2780385504 @default.
• W1973455669 hasConcept C2780942790 @default.
• W1973455669 hasConcept C2987395477 @default.
• W1973455669 hasConcept C54355233 @default.
• W1973455669 hasConcept C60644358 @default.
• W1973455669 hasConcept C70721500 @default.
• W1973455669 hasConcept C71924100 @default.
• W1973455669 hasConcept C86803240 @default.
• W1973455669 hasConcept C95371953 @default.
• W1973455669 hasConceptScore W1973455669C104317684 @default.
• W1973455669 hasConceptScore W1973455669C126322002 @default.
• W1973455669 hasConceptScore W1973455669C142724271 @default.
• W1973455669 hasConceptScore W1973455669C150194340 @default.
• W1973455669 hasConceptScore W1973455669C162317418 @default.

• next