FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973457744> ?p ?o ?g. }

• W1973457744 endingPage "117" @default.
• W1973457744 startingPage "111" @default.
• W1973457744 abstract "The genome sequence of Streptomyces coelicolor contains 18 cytochrome P450 enzymes. The recombinant CYP105N1 protein has been expressed in Escherichia coli and purified, and we report the biochemical and structural characterization of CYP105N1 from S. coelicolor. The purified protein exhibited the typical CO-binding spectrum of P450 enzymes and type I binding spectra with estradiol and a coelibactin analog. The oxidation of estradiol by CYP105N1, supported by H(2)O(2), produced estriol. The crystal structure of CYP105N1 was determined at 2.9 Å resolution. An unexpected wide open binding pocket located above the heme group was identified, with a volume of approximately 4299 Å(3). These results suggest that the large open pocket to the active site may be a key feature for easy access of the peptidyl carrier protein-bound substrate to perform the hydroxylation reaction. A molecular docking model with coelibactin showed that the phenyl group of coelibactin is located <4 Å away from the heme-iron, suggesting that CYP105N1 may be involved in the hydroxylation of the phenyl ring of the coelibactin precursor during biosynthesis." @default.
• W1973457744 created "2016-06-24" @default.
• W1973457744 creator A5006691221 @default.
• W1973457744 creator A5026038370 @default.
• W1973457744 creator A5027840923 @default.
• W1973457744 creator A5038687204 @default.
• W1973457744 creator A5040256122 @default.
• W1973457744 creator A5045361830 @default.
• W1973457744 creator A5054954881 @default.
• W1973457744 creator A5063321478 @default.
• W1973457744 creator A5085660248 @default.
• W1973457744 date "2012-12-01" @default.
• W1973457744 modified "2023-10-16" @default.
• W1973457744 title "Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway" @default.
• W1973457744 cites W1505308863 @default.
• W1973457744 cites W1547482025 @default.
• W1973457744 cites W1968513930 @default.
• W1973457744 cites W1971866201 @default.
• W1973457744 cites W1976500858 @default.
• W1973457744 cites W2000382182 @default.
• W1973457744 cites W2001641653 @default.
• W1973457744 cites W2008339958 @default.
• W1973457744 cites W2012960603 @default.
• W1973457744 cites W2016907285 @default.
• W1973457744 cites W2018304920 @default.
• W1973457744 cites W2019648113 @default.
• W1973457744 cites W2034658285 @default.
• W1973457744 cites W2041073990 @default.
• W1973457744 cites W2057810413 @default.
• W1973457744 cites W2062683863 @default.
• W1973457744 cites W2077776336 @default.
• W1973457744 cites W2080070878 @default.
• W1973457744 cites W2081526839 @default.
• W1973457744 cites W2086312371 @default.
• W1973457744 cites W2092009497 @default.
• W1973457744 cites W2114367386 @default.
• W1973457744 cites W2118465351 @default.
• W1973457744 cites W2119146976 @default.
• W1973457744 cites W2120409655 @default.
• W1973457744 cites W2128574216 @default.
• W1973457744 cites W2144081223 @default.
• W1973457744 cites W2144860443 @default.
• W1973457744 cites W2157342715 @default.
• W1973457744 cites W2162005336 @default.
• W1973457744 doi "https://doi.org/10.1016/j.abb.2012.09.001" @default.
• W1973457744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23000034" @default.
• W1973457744 hasPublicationYear "2012" @default.
• W1973457744 type Work @default.
• W1973457744 sameAs 1973457744 @default.
• W1973457744 citedByCount "19" @default.
• W1973457744 countsByYear W19734577442014 @default.
• W1973457744 countsByYear W19734577442015 @default.
• W1973457744 countsByYear W19734577442016 @default.
• W1973457744 countsByYear W19734577442017 @default.
• W1973457744 countsByYear W19734577442018 @default.
• W1973457744 countsByYear W19734577442019 @default.
• W1973457744 countsByYear W19734577442020 @default.
• W1973457744 countsByYear W19734577442022 @default.
• W1973457744 countsByYear W19734577442023 @default.
• W1973457744 crossrefType "journal-article" @default.
• W1973457744 hasAuthorship W1973457744A5006691221 @default.
• W1973457744 hasAuthorship W1973457744A5026038370 @default.
• W1973457744 hasAuthorship W1973457744A5027840923 @default.
• W1973457744 hasAuthorship W1973457744A5038687204 @default.
• W1973457744 hasAuthorship W1973457744A5040256122 @default.
• W1973457744 hasAuthorship W1973457744A5045361830 @default.
• W1973457744 hasAuthorship W1973457744A5054954881 @default.
• W1973457744 hasAuthorship W1973457744A5063321478 @default.
• W1973457744 hasAuthorship W1973457744A5085660248 @default.
• W1973457744 hasConcept C104317684 @default.
• W1973457744 hasConcept C143065580 @default.
• W1973457744 hasConcept C159110408 @default.
• W1973457744 hasConcept C181199279 @default.
• W1973457744 hasConcept C185592680 @default.
• W1973457744 hasConcept C2776217839 @default.
• W1973457744 hasConcept C2779268744 @default.
• W1973457744 hasConcept C2779920670 @default.
• W1973457744 hasConcept C2780681812 @default.
• W1973457744 hasConcept C2781109383 @default.
• W1973457744 hasConcept C41183919 @default.
• W1973457744 hasConcept C41685203 @default.
• W1973457744 hasConcept C523546767 @default.
• W1973457744 hasConcept C54355233 @default.
• W1973457744 hasConcept C547475151 @default.
• W1973457744 hasConcept C55493867 @default.
• W1973457744 hasConcept C71240020 @default.
• W1973457744 hasConcept C71924100 @default.
• W1973457744 hasConcept C86803240 @default.
• W1973457744 hasConceptScore W1973457744C104317684 @default.
• W1973457744 hasConceptScore W1973457744C143065580 @default.
• W1973457744 hasConceptScore W1973457744C159110408 @default.
• W1973457744 hasConceptScore W1973457744C181199279 @default.
• W1973457744 hasConceptScore W1973457744C185592680 @default.
• W1973457744 hasConceptScore W1973457744C2776217839 @default.
• W1973457744 hasConceptScore W1973457744C2779268744 @default.
• W1973457744 hasConceptScore W1973457744C2779920670 @default.
• W1973457744 hasConceptScore W1973457744C2780681812 @default.
• W1973457744 hasConceptScore W1973457744C2781109383 @default.

• next