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- W1973463648 abstract "Background: The effect of antiretroviral therapy on seminal HIV shedding in the community remains unknown. Objective: To evaluate the effect of antiretroviral therapy on HIV shedding in semen. Design: Prospective cohort study. Setting: University hospital in Rio de Janeiro, Brazil. Patients: 93 HIV-infected men. Intervention: Antiretroviral therapy as prescribed by each patient's physician. Measurement: HIV RNA in semen and blood plasma before and after introduction of therapy. Results: At baseline, HIV RNA was detected in 69 semen samples (74%) and 89 blood samples (96%). Six months after introduction of therapy, HIV RNA was detected in 29 semen samples (33%) and 33 blood samples (38%). The mean reduction in levels of HIV RNA in semen at 6 months was 1.65 log10 units. Conclusions: Antiretroviral therapy reduces shedding of HIV in semen, which probably in turn reduces HIV transmissibility. However, a substantial proportion of patients may still be infectious and may have drug-resistant strains of the virus." @default.
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- W1973463648 date "2000-08-15" @default.
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- W1973463648 title "Effect of Antiretroviral Therapy on HIV Shedding in Semen" @default.
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- W1973463648 doi "https://doi.org/10.7326/0003-4819-133-4-200008150-00012" @default.
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