FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973465098> ?p ?o ?g. }

• W1973465098 endingPage "601" @default.
• W1973465098 startingPage "601" @default.
• W1973465098 abstract "Activity-dependent dendritic translation in CNS neurons is important for the synapse-specific provision of proteins that may be necessary for strengthening of synaptic connections. A major rate-limiting factor during protein synthesis is the availability of eukaryotic translation initiation factor 4E (eIF4E), an mRNA 5'-cap-binding protein. In this study we show by fluorescence in situ hybridization (FISH) that the mRNA for eIF4E is present in the dendrites of cultured rat hippocampal neurons. Under basal culture conditions, 58.7 ± 11.6% of the eIF4E mRNA clusters localize with or immediately adjacent to PSD-95 clusters. Neuronal activation with KCl (60 mM, 10 min) very significantly increases the number of eIF4E mRNA clusters in dendrites by 50.1 and 74.5% at 2 and 6 h after treatment, respectively. In addition, the proportion of eIF4E mRNA clusters that localize with PSD-95 increases to 74.4 ± 7.7% and 77.8 ± 7.6% of the eIF4E clusters at 2 and 6 h after KCl treatment, respectively. Our results demonstrate the presence of eIF4E mRNA in dendrites and an activity-dependent increase of these clusters at synaptic sites. This provides a potential mechanism by which protein translation at synapses may be enhanced in response to synaptic stimulation." @default.
• W1973465098 created "2016-06-24" @default.
• W1973465098 creator A5021270019 @default.
• W1973465098 creator A5051098112 @default.
• W1973465098 creator A5067406841 @default.
• W1973465098 creator A5085079186 @default.
• W1973465098 date "2009-01-01" @default.
• W1973465098 modified "2023-10-11" @default.
• W1973465098 title "Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons" @default.
• W1973465098 cites W1636792448 @default.
• W1973465098 cites W1818286516 @default.
• W1973465098 cites W1966817364 @default.
• W1973465098 cites W1972208445 @default.
• W1973465098 cites W1978547782 @default.
• W1973465098 cites W1979496428 @default.
• W1973465098 cites W1997539008 @default.
• W1973465098 cites W1998254077 @default.
• W1973465098 cites W2006376420 @default.
• W1973465098 cites W2010185965 @default.
• W1973465098 cites W2017244521 @default.
• W1973465098 cites W2036872180 @default.
• W1973465098 cites W2038134981 @default.
• W1973465098 cites W2045085957 @default.
• W1973465098 cites W2049731104 @default.
• W1973465098 cites W2054855377 @default.
• W1973465098 cites W2061276796 @default.
• W1973465098 cites W2061791098 @default.
• W1973465098 cites W2062564388 @default.
• W1973465098 cites W2062832479 @default.
• W1973465098 cites W2066814511 @default.
• W1973465098 cites W2069243189 @default.
• W1973465098 cites W2070144984 @default.
• W1973465098 cites W2073360590 @default.
• W1973465098 cites W2086187406 @default.
• W1973465098 cites W2090496781 @default.
• W1973465098 cites W2095109616 @default.
• W1973465098 cites W2095512479 @default.
• W1973465098 cites W2095832516 @default.
• W1973465098 cites W2097557124 @default.
• W1973465098 cites W2107777962 @default.
• W1973465098 cites W2113755074 @default.
• W1973465098 cites W2114823743 @default.
• W1973465098 cites W2143823065 @default.
• W1973465098 cites W2145681254 @default.
• W1973465098 cites W2159201176 @default.
• W1973465098 cites W2161728447 @default.
• W1973465098 cites W2163833112 @default.
• W1973465098 cites W2166843521 @default.
• W1973465098 cites W2168221097 @default.
• W1973465098 cites W4256110274 @default.
• W1973465098 cites W4293156776 @default.
• W1973465098 cites W4297627084 @default.
• W1973465098 doi "https://doi.org/10.3858/emm.2009.41.8.066" @default.
• W1973465098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2739900" @default.
• W1973465098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19381064" @default.
• W1973465098 hasPublicationYear "2009" @default.
• W1973465098 type Work @default.
• W1973465098 sameAs 1973465098 @default.
• W1973465098 citedByCount "19" @default.
• W1973465098 countsByYear W19734650982012 @default.
• W1973465098 countsByYear W19734650982013 @default.
• W1973465098 countsByYear W19734650982016 @default.
• W1973465098 countsByYear W19734650982018 @default.
• W1973465098 countsByYear W19734650982019 @default.
• W1973465098 countsByYear W19734650982020 @default.
• W1973465098 countsByYear W19734650982022 @default.
• W1973465098 countsByYear W19734650982023 @default.
• W1973465098 crossrefType "journal-article" @default.
• W1973465098 hasAuthorship W1973465098A5021270019 @default.
• W1973465098 hasAuthorship W1973465098A5051098112 @default.
• W1973465098 hasAuthorship W1973465098A5067406841 @default.
• W1973465098 hasAuthorship W1973465098A5085079186 @default.
• W1973465098 hasBestOaLocation W19734650981 @default.
• W1973465098 hasConcept C104317684 @default.
• W1973465098 hasConcept C105580179 @default.
• W1973465098 hasConcept C127445978 @default.
• W1973465098 hasConcept C148762608 @default.
• W1973465098 hasConcept C149364088 @default.
• W1973465098 hasConcept C153911025 @default.
• W1973465098 hasConcept C161295673 @default.
• W1973465098 hasConcept C169760540 @default.
• W1973465098 hasConcept C185592680 @default.
• W1973465098 hasConcept C3675279 @default.
• W1973465098 hasConcept C4718897 @default.
• W1973465098 hasConcept C55493867 @default.
• W1973465098 hasConcept C62493599 @default.
• W1973465098 hasConcept C81439078 @default.
• W1973465098 hasConcept C86803240 @default.
• W1973465098 hasConcept C95444343 @default.
• W1973465098 hasConceptScore W1973465098C104317684 @default.
• W1973465098 hasConceptScore W1973465098C105580179 @default.
• W1973465098 hasConceptScore W1973465098C127445978 @default.
• W1973465098 hasConceptScore W1973465098C148762608 @default.
• W1973465098 hasConceptScore W1973465098C149364088 @default.
• W1973465098 hasConceptScore W1973465098C153911025 @default.
• W1973465098 hasConceptScore W1973465098C161295673 @default.
• W1973465098 hasConceptScore W1973465098C169760540 @default.
• W1973465098 hasConceptScore W1973465098C185592680 @default.

• next