FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973472954> ?p ?o ?g. }

• W1973472954 endingPage "1076" @default.
• W1973472954 startingPage "1067" @default.
• W1973472954 abstract "Evidence from animal studies suggests that a period of anoxia to the fetus, a consequence common to many birth complications, results in long-term alterations in ventral mesencephalic dopamine function. Long-term functional changes in these dopamine neurons, in particular those that innervate the nucleus accumbens, also occur when animals are repeatedly stressed. In the present study, we examined the possibility that a period of anoxia during a Cesarean section birth can later alter the development of stress-induced sensitization of dopamine transmission in the nucleus accumbens. Dams were decapitated on the last day of gestation and the entire uterus was removed by Cesarean section. Pups were then delivered either immediately (Cesarean section group) or were immersed in a 37°C saline bath for 3.5 or 13.5 min (Cesarean section+anoxia groups) before delivery of the pups. A fourth group of pups that were born vaginally served as controls (Vaginal group). Three to four months postnatally, animals from each group were implanted with monoamine-selective carbon-fiber electrodes into the nucleus accumbens. Voltammetry was used to monitor the dopamine response to each of five consecutive, once daily, 15-min exposures to tail-pinch stress. The results show that the first exposure to stress elicited dopamine signal increases of comparable amplitudes and durations in all animals. However, when compared to the initial stress response, the fourth and fifth exposures to tail-pinch elicited significantly longer-lasting dopamine responses in animals born by Cesarean section, either with or without added anoxia. In contrast, there was no significant day-to-day enhancement of the stress response in control, vaginally born animals. The findings reported here provide experimental support for the idea that birth complications may contribute to the pathophysiology of psychiatric disorders, in particular those that involve central dopamine dysfunction, such as schizophrenia. Specifically, our results suggest that subtle alterations in birth procedure may be sufficient to increase the sensitivity of mesolimbic dopamine neurons to the effects of repeated stress in the adult animal." @default.
• W1973472954 created "2016-06-24" @default.
• W1973472954 creator A5038003670 @default.
• W1973472954 creator A5063809087 @default.
• W1973472954 creator A5084766334 @default.
• W1973472954 creator A5087429528 @default.
• W1973472954 date "1997-02-01" @default.
• W1973472954 modified "2023-09-23" @default.
• W1973472954 title "Influence of perinatal factors on the nucleus accumbens dopamine response to repeated stress during adulthood: an electrochemical study in the rat" @default.
• W1973472954 cites W1511472979 @default.
• W1973472954 cites W189363520 @default.
• W1973472954 cites W1939900967 @default.
• W1973472954 cites W1964299025 @default.
• W1973472954 cites W1965926569 @default.
• W1973472954 cites W1974348633 @default.
• W1973472954 cites W1980325453 @default.
• W1973472954 cites W1981648513 @default.
• W1973472954 cites W1982019262 @default.
• W1973472954 cites W1983302605 @default.
• W1973472954 cites W1985061465 @default.
• W1973472954 cites W1985082981 @default.
• W1973472954 cites W1985803034 @default.
• W1973472954 cites W1988081931 @default.
• W1973472954 cites W1990307643 @default.
• W1973472954 cites W1994429247 @default.
• W1973472954 cites W1997342733 @default.
• W1973472954 cites W2002565017 @default.
• W1973472954 cites W2003488688 @default.
• W1973472954 cites W2016635401 @default.
• W1973472954 cites W2020638145 @default.
• W1973472954 cites W2036538596 @default.
• W1973472954 cites W2041369842 @default.
• W1973472954 cites W2046534974 @default.
• W1973472954 cites W2049854645 @default.
• W1973472954 cites W2052099737 @default.
• W1973472954 cites W2069548617 @default.
• W1973472954 cites W2074782745 @default.
• W1973472954 cites W2077989962 @default.
• W1973472954 cites W2092279314 @default.
• W1973472954 cites W2092902644 @default.
• W1973472954 cites W2093780531 @default.
• W1973472954 cites W2094551470 @default.
• W1973472954 cites W2096029767 @default.
• W1973472954 cites W2127311689 @default.
• W1973472954 cites W2130259686 @default.
• W1973472954 cites W2132122521 @default.
• W1973472954 cites W2134231898 @default.
• W1973472954 cites W2138921838 @default.
• W1973472954 cites W2150598978 @default.
• W1973472954 cites W2151331628 @default.
• W1973472954 cites W2165732068 @default.
• W1973472954 cites W2277546886 @default.
• W1973472954 doi "https://doi.org/10.1016/s0306-4522(96)00543-x" @default.
• W1973472954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9130788" @default.
• W1973472954 hasPublicationYear "1997" @default.
• W1973472954 type Work @default.
• W1973472954 sameAs 1973472954 @default.
• W1973472954 citedByCount "66" @default.
• W1973472954 countsByYear W19734729542012 @default.
• W1973472954 countsByYear W19734729542013 @default.
• W1973472954 countsByYear W19734729542014 @default.
• W1973472954 countsByYear W19734729542015 @default.
• W1973472954 countsByYear W19734729542016 @default.
• W1973472954 countsByYear W19734729542017 @default.
• W1973472954 countsByYear W19734729542018 @default.
• W1973472954 countsByYear W19734729542020 @default.
• W1973472954 countsByYear W19734729542022 @default.
• W1973472954 crossrefType "journal-article" @default.
• W1973472954 hasAuthorship W1973472954A5038003670 @default.
• W1973472954 hasAuthorship W1973472954A5063809087 @default.
• W1973472954 hasAuthorship W1973472954A5084766334 @default.
• W1973472954 hasAuthorship W1973472954A5087429528 @default.
• W1973472954 hasConcept C126322002 @default.
• W1973472954 hasConcept C134018914 @default.
• W1973472954 hasConcept C170493617 @default.
• W1973472954 hasConcept C2775841634 @default.
• W1973472954 hasConcept C2775864247 @default.
• W1973472954 hasConcept C2775894120 @default.
• W1973472954 hasConcept C2775905480 @default.
• W1973472954 hasConcept C2776552330 @default.
• W1973472954 hasConcept C2779234561 @default.
• W1973472954 hasConcept C42219234 @default.
• W1973472954 hasConcept C46973012 @default.
• W1973472954 hasConcept C513476851 @default.
• W1973472954 hasConcept C54355233 @default.
• W1973472954 hasConcept C71924100 @default.
• W1973472954 hasConcept C86803240 @default.
• W1973472954 hasConceptScore W1973472954C126322002 @default.
• W1973472954 hasConceptScore W1973472954C134018914 @default.
• W1973472954 hasConceptScore W1973472954C170493617 @default.
• W1973472954 hasConceptScore W1973472954C2775841634 @default.
• W1973472954 hasConceptScore W1973472954C2775864247 @default.
• W1973472954 hasConceptScore W1973472954C2775894120 @default.
• W1973472954 hasConceptScore W1973472954C2775905480 @default.
• W1973472954 hasConceptScore W1973472954C2776552330 @default.
• W1973472954 hasConceptScore W1973472954C2779234561 @default.
• W1973472954 hasConceptScore W1973472954C42219234 @default.
• W1973472954 hasConceptScore W1973472954C46973012 @default.

• next