FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973473486> ?p ?o ?g. }

• W1973473486 endingPage "199" @default.
• W1973473486 startingPage "191" @default.
• W1973473486 abstract "CD8+ T cell synthesis of IFN-γ is an important component of the CD8+ T cell immune response. In short-term cultures of murine pan-T cells, we found that IL-4 was the principal cytokine responsible for driving IFN-γ synthesis by CD3/CD28-activated CD8+ T cells. IL-4 was able to induce low levels of IFN-γ mRNA in CD8+ T cells even in the absence of CD3/CD28 engagement, although concomitant CD3/CD28 stimulation was necessary for IFN-γ secretion. IL-4 induction of IFN-γ was explained by its ability to induce Eomesodermin and T-bet transcription factors whose expression was further increased by CD3/CD28. Expression of Eomesodermin, T-bet and IFN-γ induced by IL-4 was partially dependent upon activation of MAPK and PI3K but independent of the canonical IL-4-activated transcription factor, STAT6. In contrast, expression of IFN-γ induced by IL-4/CD3/CD28 stimulation showed additional dependency upon STAT6 which functions to increase expression of Eomesodermin specifically. These novel findings point to a function for IL-4 as a direct regulator of IFN-γ expression in CD8+ T cells and reveal the molecular mechanisms involved." @default.
• W1973473486 created "2016-06-24" @default.
• W1973473486 creator A5044846381 @default.
• W1973473486 creator A5054506868 @default.
• W1973473486 creator A5060501266 @default.
• W1973473486 creator A5062964311 @default.
• W1973473486 date "2012-01-01" @default.
• W1973473486 modified "2023-09-27" @default.
• W1973473486 title "IL-4 acts as a potent stimulator of IFN-γ expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet" @default.
• W1973473486 cites W1510276262 @default.
• W1973473486 cites W1549272413 @default.
• W1973473486 cites W1845629018 @default.
• W1973473486 cites W1916415226 @default.
• W1973473486 cites W1941785397 @default.
• W1973473486 cites W2008667095 @default.
• W1973473486 cites W2009559036 @default.
• W1973473486 cites W2012228539 @default.
• W1973473486 cites W2019884726 @default.
• W1973473486 cites W2040887800 @default.
• W1973473486 cites W2043201613 @default.
• W1973473486 cites W2046568838 @default.
• W1973473486 cites W2067049479 @default.
• W1973473486 cites W2071112640 @default.
• W1973473486 cites W2077916154 @default.
• W1973473486 cites W2085345039 @default.
• W1973473486 cites W2086121828 @default.
• W1973473486 cites W2089367238 @default.
• W1973473486 cites W2090697609 @default.
• W1973473486 cites W2097814320 @default.
• W1973473486 cites W2106166533 @default.
• W1973473486 cites W2106183372 @default.
• W1973473486 cites W2114570899 @default.
• W1973473486 cites W2119542365 @default.
• W1973473486 cites W2143352405 @default.
• W1973473486 cites W2145611033 @default.
• W1973473486 cites W2158969445 @default.
• W1973473486 cites W2160281115 @default.
• W1973473486 cites W2170266529 @default.
• W1973473486 cites W4240209814 @default.
• W1973473486 doi "https://doi.org/10.1016/j.cyto.2011.10.006" @default.
• W1973473486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246089" @default.
• W1973473486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22078635" @default.
• W1973473486 hasPublicationYear "2012" @default.
• W1973473486 type Work @default.
• W1973473486 sameAs 1973473486 @default.
• W1973473486 citedByCount "24" @default.
• W1973473486 countsByYear W19734734862012 @default.
• W1973473486 countsByYear W19734734862013 @default.
• W1973473486 countsByYear W19734734862014 @default.
• W1973473486 countsByYear W19734734862015 @default.
• W1973473486 countsByYear W19734734862018 @default.
• W1973473486 countsByYear W19734734862019 @default.
• W1973473486 countsByYear W19734734862021 @default.
• W1973473486 countsByYear W19734734862022 @default.
• W1973473486 crossrefType "journal-article" @default.
• W1973473486 hasAuthorship W1973473486A5044846381 @default.
• W1973473486 hasAuthorship W1973473486A5054506868 @default.
• W1973473486 hasAuthorship W1973473486A5060501266 @default.
• W1973473486 hasAuthorship W1973473486A5062964311 @default.
• W1973473486 hasBestOaLocation W19734734862 @default.
• W1973473486 hasConcept C114684123 @default.
• W1973473486 hasConcept C148125776 @default.
• W1973473486 hasConcept C153911025 @default.
• W1973473486 hasConcept C154317977 @default.
• W1973473486 hasConcept C167672396 @default.
• W1973473486 hasConcept C191732599 @default.
• W1973473486 hasConcept C202751555 @default.
• W1973473486 hasConcept C203014093 @default.
• W1973473486 hasConcept C2776090121 @default.
• W1973473486 hasConcept C2778690821 @default.
• W1973473486 hasConcept C55493867 @default.
• W1973473486 hasConcept C86803240 @default.
• W1973473486 hasConcept C8891405 @default.
• W1973473486 hasConcept C95444343 @default.
• W1973473486 hasConceptScore W1973473486C114684123 @default.
• W1973473486 hasConceptScore W1973473486C148125776 @default.
• W1973473486 hasConceptScore W1973473486C153911025 @default.
• W1973473486 hasConceptScore W1973473486C154317977 @default.
• W1973473486 hasConceptScore W1973473486C167672396 @default.
• W1973473486 hasConceptScore W1973473486C191732599 @default.
• W1973473486 hasConceptScore W1973473486C202751555 @default.
• W1973473486 hasConceptScore W1973473486C203014093 @default.
• W1973473486 hasConceptScore W1973473486C2776090121 @default.
• W1973473486 hasConceptScore W1973473486C2778690821 @default.
• W1973473486 hasConceptScore W1973473486C55493867 @default.
• W1973473486 hasConceptScore W1973473486C86803240 @default.
• W1973473486 hasConceptScore W1973473486C8891405 @default.
• W1973473486 hasConceptScore W1973473486C95444343 @default.
• W1973473486 hasFunder F4320332161 @default.
• W1973473486 hasIssue "1" @default.
• W1973473486 hasLocation W19734734861 @default.
• W1973473486 hasLocation W19734734862 @default.
• W1973473486 hasLocation W19734734863 @default.
• W1973473486 hasLocation W19734734864 @default.
• W1973473486 hasOpenAccess W1973473486 @default.
• W1973473486 hasPrimaryLocation W19734734861 @default.
• W1973473486 hasRelatedWork W1505145311 @default.
• W1973473486 hasRelatedWork W1998117339 @default.

• next