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- W1973477190 abstract "Previous studies have demonstrated the efficacy of two thymidine analogs, 5-iododeoxyuridine (IdUrd) and 5-bromodeoxyuridine (BrdUrd), as inducers of murine leukemia virus (MLV) synthesis in virus-negative cell clones derived from AKR mouse embryos. The results of screening other compounds, such as other base analogs, chemical carcinogens, and mutagens, demonstrate that these two thymidine analogs are by far the most efficient inducers of MLV synthesis in these cells. To obtain maximal activation of virus synthesis by the thymidine analogs, it was necessary to define both the optimal level of drug and time of exposure for each cell system.The studies presented here indicate that incorporation of IdUrd or BrdUrd into cellular DNA plays a vital role in the activation of murine leukemia virus production in the AKR cell lines. (1) If DNA synthesis is blocked or decreased by cytosine arabinoside or serum depletion during the halogenated pyrimidine treatment, the proportion of cells activated is diminished. (2) When analog incorporation into DNA is blocked by simultaneous treatment with thymidine, no induction of virus occurs. (3) When analog incorporation into DNA is enhanced by simultaneous treatment with fluorodeoxyuridine, the proportion of cells induced to produce virus is significantly increased. (4) When cells containing analog-substituted DNA are irradiated with visible light or X-rays, the number of cells activated also increases." @default.
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- W1973477190 date "1990-07-01" @default.
- W1973477190 modified "2023-09-26" @default.
- W1973477190 title "Heparin-sensitive and -insensitive growth stimulation of smooth muscle cells in a carotid artery culture system" @default.
- W1973477190 doi "https://doi.org/10.1016/0014-2999(90)92458-u" @default.
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