FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973477322> ?p ?o ?g. }

• W1973477322 endingPage "799" @default.
• W1973477322 startingPage "793" @default.
• W1973477322 abstract "MiRNAs located at chromosome fragile sites play important roles in regulating critical genes associated with myeloma pathogenesis, disease progression and drug resistance. Our previous results have identified miR-33b (located in chromosome 17p) was one of the dysregulated miRNAs in the sera of newly diagnosed MM patients. However, little is known about its expression pattern in myeloma tumor cells and its prognostic value in MM patients. In the present study, we investigated the expression pattern of miR-33b in 58 newly diagnosed, 11 relapsed, 12 remission MM patients and 18 health donors by quantitative real-time PCR. Our results showed the expression of miR-33b was obviously down-regulated in newly diagnosed and relapsed MM patients compared to remission patients and health donors (p<0.001). Moreover, patients with del(13q), del(17p), t(4;14) and high-risk genetic abnormalities have lower expression levels of miR-33b compared to patients without those of abnormalities (p=0.032, 0.018, 0.034, 0.005). Survival analysis showed patients with miR-33b low expression had significantly shortened PFS (p=0.016) and OS (p=0.033) and might be associated with drug resistance to bortezomib-based treatment. Our data suggest that down-regulated miR-33b might be a novel predictor associated with disease progression and poor prognosis in MM." @default.
• W1973477322 created "2016-06-24" @default.
• W1973477322 creator A5000632526 @default.
• W1973477322 creator A5000802348 @default.
• W1973477322 creator A5002787785 @default.
• W1973477322 creator A5002960038 @default.
• W1973477322 creator A5005228021 @default.
• W1973477322 creator A5005476912 @default.
• W1973477322 creator A5008198016 @default.
• W1973477322 creator A5017214725 @default.
• W1973477322 creator A5017804632 @default.
• W1973477322 creator A5030223228 @default.
• W1973477322 creator A5030715375 @default.
• W1973477322 creator A5044751148 @default.
• W1973477322 creator A5044809089 @default.
• W1973477322 creator A5081366427 @default.
• W1973477322 date "2015-07-01" @default.
• W1973477322 modified "2023-10-18" @default.
• W1973477322 title "Downregulated miR-33b is a novel predictor associated with disease progression and poor prognosis in multiple myeloma" @default.
• W1973477322 cites W1947478323 @default.
• W1973477322 cites W1977691688 @default.
• W1973477322 cites W1984892611 @default.
• W1973477322 cites W1989336885 @default.
• W1973477322 cites W1990009253 @default.
• W1973477322 cites W1990793727 @default.
• W1973477322 cites W1994039406 @default.
• W1973477322 cites W2010570442 @default.
• W1973477322 cites W2026570544 @default.
• W1973477322 cites W2027799031 @default.
• W1973477322 cites W2041081193 @default.
• W1973477322 cites W2042748226 @default.
• W1973477322 cites W2045999249 @default.
• W1973477322 cites W2052825822 @default.
• W1973477322 cites W2074277423 @default.
• W1973477322 cites W2075728036 @default.
• W1973477322 cites W2077202176 @default.
• W1973477322 cites W2082010591 @default.
• W1973477322 cites W2090363187 @default.
• W1973477322 cites W2095281683 @default.
• W1973477322 cites W2102901373 @default.
• W1973477322 cites W2108008692 @default.
• W1973477322 cites W2109578585 @default.
• W1973477322 cites W2127008908 @default.
• W1973477322 cites W2129488464 @default.
• W1973477322 cites W2140568894 @default.
• W1973477322 cites W2148565111 @default.
• W1973477322 cites W2150536104 @default.
• W1973477322 cites W2152091242 @default.
• W1973477322 cites W2154694480 @default.
• W1973477322 cites W2163375473 @default.
• W1973477322 cites W2963552158 @default.
• W1973477322 cites W4367435876 @default.
• W1973477322 doi "https://doi.org/10.1016/j.leukres.2015.04.010" @default.
• W1973477322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25975752" @default.
• W1973477322 hasPublicationYear "2015" @default.
• W1973477322 type Work @default.
• W1973477322 sameAs 1973477322 @default.
• W1973477322 citedByCount "22" @default.
• W1973477322 countsByYear W19734773222015 @default.
• W1973477322 countsByYear W19734773222016 @default.
• W1973477322 countsByYear W19734773222017 @default.
• W1973477322 countsByYear W19734773222018 @default.
• W1973477322 countsByYear W19734773222019 @default.
• W1973477322 countsByYear W19734773222020 @default.
• W1973477322 countsByYear W19734773222021 @default.
• W1973477322 countsByYear W19734773222022 @default.
• W1973477322 countsByYear W19734773222023 @default.
• W1973477322 crossrefType "journal-article" @default.
• W1973477322 hasAuthorship W1973477322A5000632526 @default.
• W1973477322 hasAuthorship W1973477322A5000802348 @default.
• W1973477322 hasAuthorship W1973477322A5002787785 @default.
• W1973477322 hasAuthorship W1973477322A5002960038 @default.
• W1973477322 hasAuthorship W1973477322A5005228021 @default.
• W1973477322 hasAuthorship W1973477322A5005476912 @default.
• W1973477322 hasAuthorship W1973477322A5008198016 @default.
• W1973477322 hasAuthorship W1973477322A5017214725 @default.
• W1973477322 hasAuthorship W1973477322A5017804632 @default.
• W1973477322 hasAuthorship W1973477322A5030223228 @default.
• W1973477322 hasAuthorship W1973477322A5030715375 @default.
• W1973477322 hasAuthorship W1973477322A5044751148 @default.
• W1973477322 hasAuthorship W1973477322A5044809089 @default.
• W1973477322 hasAuthorship W1973477322A5081366427 @default.
• W1973477322 hasConcept C104317684 @default.
• W1973477322 hasConcept C114851261 @default.
• W1973477322 hasConcept C121608353 @default.
• W1973477322 hasConcept C126322002 @default.
• W1973477322 hasConcept C143998085 @default.
• W1973477322 hasConcept C145059251 @default.
• W1973477322 hasConcept C203014093 @default.
• W1973477322 hasConcept C2776364478 @default.
• W1973477322 hasConcept C2777478702 @default.
• W1973477322 hasConcept C2779134260 @default.
• W1973477322 hasConcept C2779256057 @default.
• W1973477322 hasConcept C2780942790 @default.
• W1973477322 hasConcept C54355233 @default.
• W1973477322 hasConcept C71924100 @default.
• W1973477322 hasConcept C86803240 @default.
• W1973477322 hasConceptScore W1973477322C104317684 @default.

• next