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- W1973482952 abstract "Treatments that raise or lower brain tyrosine concentrations in rats cause parallel changes in the rates at which their brains accumulate DOPA (after aromatic L-amino acid decarboxylase is inhibited by RO4-4602). When the neutral amino acid drug ρ-chlorophenylalanine (PCPA) was injected i.p. into rats (100mg/kg), it decreased brain tyrosine concentrations over a wide range, partly by competing with tyrosine for uptake into the brain. Brain DOPA accumulation after RO4-4602 decreased in parallel. At this dosage, PCPA did not inhibit tyrosine hydroxylase activity in vivo, and, at very high concentrations (10−3 M) in vitro, it inhibited the enzyme only slightly. Hence, the decrease in DOPA accumulation probably derived from a decrease in the availability of tyrosine (the substrate for tyrosine hydroxylase) rather than from a change in enzyme activity. Similarly, the neutral amino acids, valine and isoleucine (which have been used previously to modify brain tyrosine concentrations and, hence, catechol synthesis), had no effect on tyrosine hydroxylase activity in vitro in concentrations up to 10−3 M. At high concentrations (10−3 M), leucine slightly inhibited the enzyme. When rats ingested a single meal containing 40 per cent casein, their brain evidenced increases in both tyrosine levels and catechol synthesis. Thus, the availability of tyrosine to the brain may be one of the factors normally controlling brain catecholamine synthesis." @default.
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- W1973482952 date "1977-06-01" @default.
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- W1973482952 title "Physiological control of brain catechol synthesis by brain tyrosine concentration" @default.
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- W1973482952 doi "https://doi.org/10.1016/0006-2952(77)90057-0" @default.
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