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• W1973483954 abstract "Determinar las concentraciones de lipoproteína(a) (Lp[a]) en una muestra de población adulta cubana con dislipemia. Se estudió a 170 pacientes con concentraciones de colesterol total > 6,2 mmol/l y de cLDL > 3,4 mmol/l, y 197 individuos con colesterol 5,2 mmol/l y triglicéridos 2,3 mmol/l, como grupo control. Se determinaron las concentraciones de colesterol, triglicéridos, colesterol de alta densidad (cHDL), apolipoproteína B-100 (apo B-100) y Lp(a) y se calculó el cLDL por la fórmula de Friedewald. Se obtuvieron diferencias significativas (p 0,0001) para la Lp(a) entre pacientes y controles (54,44 ± 36,93 frente a 31,08 ± 27,79 mg/dl), diferencias que se mantuvieron para cada sexo por separado. Se demostró una fuerte correlación de la Lp(a) con el cLDL y la apo B-100 y, en menor grado, con el colesterol total sólo en los pacientes dislipémicos. El histograma de frecuencia en los pacientes mostró una tendencia a la desviación hacia la derecha (valores más altos), mientras en los controles, esta desviación a la izquierda. Finalmente, se encontró valor promedio de Lp(a) más elevado en el subgrupo de individuos hipertrigliceridémicos, al compararlo con los normotrigliceridémicos. La muestra de población cubana analizada presentó concentraciones séricas de Lp(a) elevadas, tanto en pacientes hipercolesterolémicos como hipertrigliceridémicos. To determine concentrations of lipoprotein(a) [Lp(a)] in a sample of the adult Cuban population with dyslipidemia. We studied 170 patients with total cholesterol concentrations of > 6.2 mmol/L and low-density lipoprotein (LDL) cholesterol of > 3.4 mmol/L and 197 individuals with cholesterol levels of 5.2 mmol/L and triglyceride levels of 2.3 mmol/L as a control group. Concentrations of cholesterol, triglycerides, highdensity lipoprotein (HDL) cholesterol, apolipoprotein B-100 (Apo B-100) and Lp(a) were determined and LDL cholesterol was calculated using Friedewald’s formula. Significant differences (p 0.0001) were obtained for Lp(a) between patients and controls (54.44 ± 36.93 vs 31.08 ± 27.79 mg/dl) and these differences were maintained when each sex was analyzed separately. A strong correlation was found between Lp(a) and LDL cholesterol and Apo B-100 and to a lesser extent with total cholesterol in dyslipidemic patients only. Frequency histogram in patients showed a tendency to deviation toward the right (higher values) while in controls, deviation was toward the left. Finally, a higher mean value of Lp(a) was found in the subgroup of hypertriglyceridemic individuals compared with those with normal triglyceride levels. The sample of the Cuban population analyzed showed elevated serum concentrations of Lp(a) both in patients with hypercholesterolemia and in those with hypertriglyceridemia." @default.
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• W1973483954 date "2003-01-01" @default.
• W1973483954 modified "2023-09-23" @default.
• W1973483954 title "Concentraciones séricas de lipoproteína(a) en pacientes cubanos dislipémicos" @default.
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• W1973483954 doi "https://doi.org/10.1016/s0214-9168(03)78934-7" @default.
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