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• W1973484999 endingPage "528" @default.
• W1973484999 startingPage "528" @default.
• W1973484999 abstract "Amplified fragment length polymorphism (AFLP) markers are frequently used for a wide range of studies, such as genome-wide mapping, population genetic diversity estimation, hybridization and introgression studies, phylogenetic analyses, and detection of signatures of selection. An important issue to be addressed for some of these fields is the distribution of the markers across the genome, particularly in relation to gene sequences. Using in-silico restriction fragment analysis of the genomes of nine eukaryotic species we characterise the distribution of AFLP fragments across the genome and, particularly, in relation to gene locations. First, we identify the physical position of markers across the chromosomes of all species. An observed accumulation of fragments around (peri) centromeric regions in some species is produced by repeated sequences, and this accumulation disappears when AFLP bands rather than fragments are considered. Second, we calculate the percentage of AFLP markers positioned within gene sequences. For the typical Eco RI/Mse I enzyme pair, this ranges between 28 and 87% and is usually larger than that expected by chance because of the higher GC content of gene sequences relative to intergenic ones. In agreement with this, the use of enzyme pairs with GC-rich restriction sites substantially increases the above percentages. For example, using the enzyme system Sac I/Hpa II, 86% of AFLP markers are located within gene sequences in A. thaliana, and 100% of markers in Plasmodium falciparun. We further find that for a typical trait controlled by 50 genes of average size, if 1000 AFLPs are used in a study, the number of those within 1 kb distance from any of the genes would be only about 1–2, and only about 50% of the genes would have markers within that distance. The high coverage of AFLP markers across the genomes and the high proportion of markers within or close to gene sequences make them suitable for genome scans and detecting large islands of differentiation in the genome. However, for specific traits, the percentage of AFLP markers close to genes can be rather small. Therefore, genome scans directed towards the search of markers closely linked to selected loci can be a difficult task in many instances." @default.
• W1973484999 created "2016-06-24" @default.
• W1973484999 creator A5006529771 @default.
• W1973484999 creator A5050213001 @default.
• W1973484999 creator A5065043004 @default.
• W1973484999 date "2013-01-01" @default.
• W1973484999 modified "2023-10-06" @default.
• W1973484999 title "Genomic distribution of AFLP markers relative to gene locations for different eukaryotic species" @default.
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• W1973484999 doi "https://doi.org/10.1186/1471-2164-14-528" @default.
• W1973484999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3750350" @default.
• W1973484999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24060007" @default.
• W1973484999 hasPublicationYear "2013" @default.
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