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• W1973486382 abstract "Stem cells accumulate mitochondrial DNA (mtDNA) mutations resulting in an observable respiratory chain defect in their progeny, allowing the mapping of stem cell fate. There is considerable uncertainty in prostate epithelial biology where both basal and luminal stem cells have been described, and in this study the clonal relationships within the human prostate epithelial cell layers were explored by tracing stem cell fate. Fresh-frozen and formalin-fixed histologically-benign prostate samples from 35 patients were studied using sequential cytochrome c oxidase (COX)/succinate dehydrogenase (SDH) enzyme histochemistry and COX subunit I immunofluorescence to identify areas of respiratory chain deficiency; mtDNA mutations were identified by whole mitochondrial genome sequencing of laser-captured areas. We demonstrated that cells with respiratory chain defects due to somatic mtDNA point mutations were present in prostate epithelia and clonally expand in acini. Lineage tracing revealed distinct patterning of stem cell fate with mtDNA mutations spreading throughout the whole acinus or, more commonly, present as mosaic acinar defects. This suggests that individual acini are typically generated from multiple stem cells, and the presence of whole COX-deficient acini suggests that a single stem cell can also generate an entire branching acinar subunit of the gland. Significantly, a common clonal origin for basal, luminal and neuroendocrine cells is demonstrated, helping to resolve a key area of debate in human prostate stem cell biology." @default.
• W1973486382 created "2016-06-24" @default.
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• W1973486382 date "2011-09-06" @default.
• W1973486382 modified "2023-09-27" @default.
• W1973486382 title "In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells" @default.
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• W1973486382 doi "https://doi.org/10.1002/path.2965" @default.
• W1973486382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21898876" @default.
• W1973486382 hasPublicationYear "2011" @default.
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