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- W1973492009 abstract "E-mail: mostafa1705@yahoo.comReceived November 15, 2010, Accepted March 7, 2011A series of 1,4-disubstituted octahydroquinoxaline-2,3-dione derivatives was prepared through two stepsreaction. The latter involves the formation of N,N-disubstituted cyclohexane-1,2-diamine derivatives (la-j)through reductive alkylation of 1,2-cyclohexanediamine with different aldehydes in presence of sodiumcyanoborohydride. Fusion of compounds (1a-j) with diethyl oxalate affording the target compounds (2a-j).Elucidation of structures of compounds (2a-j) was based upon different spectral data as well as the elementalmethods of analyses. In addition, mass spectrometry and X-ray diffraction analyses were carried out.Moreover, the lipophilicity of the target compounds as expressed from the Clog P. Most of the test compounds(2a-j) showed weak to moderate antibacterial and antifungal activities against most of the used bacterial andfungal strains in comparison to chloramphenicol and clotrimazole as reference drugs respectively. Key Words : Antimicrobial, Activity, Octahydroquinoxaline-2,3-dione, Diffraction, SynthesisIntroductionThe emergence of microbial resistance is an evolutionaryprocess based on selection for organisms that have enhancedability to survive doses of antibiotics that would havepreviously been lethal. Survival of bacteria often resultsfrom an inheritable resistance." @default.
- W1973492009 created "2016-06-24" @default.
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- W1973492009 date "2011-09-29" @default.
- W1973492009 modified "2023-09-25" @default.
- W1973492009 title "ChemInform Abstract: Design, Synthesis, and Antimicrobial Activity, of New 1,4-Disubstituted Octahydroquinoxaline-2,3-dione Derivatives." @default.
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- W1973492009 doi "https://doi.org/10.1002/chin.201143156" @default.
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