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- W1973502015 abstract "Cellular studies have long been performed on the bench top, within Petri dishes and flasks that expose cells to surroundings that differ greatly from their native environment. The complexity of a human tissue is such that to truly replicate a cell’s physiologic microenvironment in vitro is currently impossible. It is nevertheless important to determine how various factors of the microenvironment interact to drive cell behavior, particularly with regard to disease states, such as cancer. Here we focus on two key elements of the cellular microenvironment, matrix stiffness and architecture, in the context of tumor cell behavior. We discuss recent work focusing on the effects of these individual properties on cancer cell migration and describe one technique developed by our lab that could be applied to dissect the effects of specific structural and mechanical cues, and which may lead to useful insights into the potentially synergistic effects of these properties on tumor cell behavior." @default.
- W1973502015 created "2016-06-24" @default.
- W1973502015 creator A5035287010 @default.
- W1973502015 creator A5047533639 @default.
- W1973502015 date "2012-05-01" @default.
- W1973502015 modified "2023-10-10" @default.
- W1973502015 title "Controlling matrix stiffness and topography for the study of tumor cell migration" @default.
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- W1973502015 doi "https://doi.org/10.4161/cam.21076" @default.
- W1973502015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3427241" @default.
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