FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973504804> ?p ?o ?g. }

• W1973504804 abstract "Hepatocytes were isolated from nafenopin-treated animals (80 mg/kg body weight in 1.2 ml/kg body weight olive oil for 2 consecutive days) and exposed to various doses of 1,2 dichloroethane (DCE) (64-159 mumol) and 1,2-dibromoethane (DBE) (5.5-27.5 mumol) for up to 3 hr to assess the effect of nafenopin on the toxicity of dihaloalkanes. The activity of biotransformation enzymes involved in the activation and detoxication of these solvents was measured. Although cytochrome P450IIE1 activity was apparently unaltered, glutathione S-transferase activity was significantly reduced; the reduction was 20% for 1-chloro-2,4-dinitrobenzene as substrate but 40% and 80%, respectively for DBE and DCE. DBE was more than 10 times more cytotoxic to nafenopin-treated hepatocytes than DCE, and while very little change in DCE cytotoxicity was observed in hepatocytes isolated from nafenopin pretreated rats compared with control animals, DBE cytotoxicity was significantly potentiated in cells isolated from nafenopin-pretreated rats compared with cells from controls. It is believed that enhanced toxicity of DBE in isolated cells from nafenopin-treated rats is the result of modulation of dihaloalkane metabolism (glutathione conjugation)." @default.
• W1973504804 created "2016-06-24" @default.
• W1973504804 creator A5001782977 @default.
• W1973504804 creator A5020279642 @default.
• W1973504804 creator A5028282565 @default.
• W1973504804 date "1996-10-01" @default.
• W1973504804 modified "2023-09-24" @default.
• W1973504804 title "Effect of peroxisome proliferator nafenopin on the cytotoxicity of dihaloalkanes in isolated rat hepatocytes" @default.
• W1973504804 cites W1505590932 @default.
• W1973504804 cites W1581414347 @default.
• W1973504804 cites W1596364582 @default.
• W1973504804 cites W1775749144 @default.
• W1973504804 cites W1964272962 @default.
• W1973504804 cites W1966901740 @default.
• W1973504804 cites W1970148223 @default.
• W1973504804 cites W1975572796 @default.
• W1973504804 cites W1984090424 @default.
• W1973504804 cites W2029058276 @default.
• W1973504804 cites W2045984034 @default.
• W1973504804 cites W2056185391 @default.
• W1973504804 cites W2058239646 @default.
• W1973504804 cites W2063968265 @default.
• W1973504804 cites W2065350734 @default.
• W1973504804 cites W2068669347 @default.
• W1973504804 cites W2069104781 @default.
• W1973504804 cites W2072482644 @default.
• W1973504804 cites W2073755865 @default.
• W1973504804 cites W2081318196 @default.
• W1973504804 cites W2081540562 @default.
• W1973504804 cites W2102978060 @default.
• W1973504804 cites W2116643260 @default.
• W1973504804 cites W2134213048 @default.
• W1973504804 cites W2166415297 @default.
• W1973504804 cites W322765721 @default.
• W1973504804 cites W62982708 @default.
• W1973504804 doi "https://doi.org/10.1016/s0887-2333(96)00037-9" @default.
• W1973504804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20650239" @default.
• W1973504804 hasPublicationYear "1996" @default.
• W1973504804 type Work @default.
• W1973504804 sameAs 1973504804 @default.
• W1973504804 citedByCount "0" @default.
• W1973504804 crossrefType "journal-article" @default.
• W1973504804 hasAuthorship W1973504804A5001782977 @default.
• W1973504804 hasAuthorship W1973504804A5020279642 @default.
• W1973504804 hasAuthorship W1973504804A5028282565 @default.
• W1973504804 hasConcept C109316439 @default.
• W1973504804 hasConcept C134018914 @default.
• W1973504804 hasConcept C178790620 @default.
• W1973504804 hasConcept C181199279 @default.
• W1973504804 hasConcept C185592680 @default.
• W1973504804 hasConcept C202751555 @default.
• W1973504804 hasConcept C27881333 @default.
• W1973504804 hasConcept C29730261 @default.
• W1973504804 hasConcept C526171541 @default.
• W1973504804 hasConcept C538909803 @default.
• W1973504804 hasConcept C55493867 @default.
• W1973504804 hasConcept C62231903 @default.
• W1973504804 hasConcept C86803240 @default.
• W1973504804 hasConcept C98274493 @default.
• W1973504804 hasConceptScore W1973504804C109316439 @default.
• W1973504804 hasConceptScore W1973504804C134018914 @default.
• W1973504804 hasConceptScore W1973504804C178790620 @default.
• W1973504804 hasConceptScore W1973504804C181199279 @default.
• W1973504804 hasConceptScore W1973504804C185592680 @default.
• W1973504804 hasConceptScore W1973504804C202751555 @default.
• W1973504804 hasConceptScore W1973504804C27881333 @default.
• W1973504804 hasConceptScore W1973504804C29730261 @default.
• W1973504804 hasConceptScore W1973504804C526171541 @default.
• W1973504804 hasConceptScore W1973504804C538909803 @default.
• W1973504804 hasConceptScore W1973504804C55493867 @default.
• W1973504804 hasConceptScore W1973504804C62231903 @default.
• W1973504804 hasConceptScore W1973504804C86803240 @default.
• W1973504804 hasConceptScore W1973504804C98274493 @default.
• W1973504804 hasLocation W19735048041 @default.
• W1973504804 hasLocation W19735048042 @default.
• W1973504804 hasOpenAccess W1973504804 @default.
• W1973504804 hasPrimaryLocation W19735048041 @default.
• W1973504804 hasRelatedWork W1968406884 @default.
• W1973504804 hasRelatedWork W1969763404 @default.
• W1973504804 hasRelatedWork W1978108260 @default.
• W1973504804 hasRelatedWork W1979182802 @default.
• W1973504804 hasRelatedWork W1980821582 @default.
• W1973504804 hasRelatedWork W1996444663 @default.
• W1973504804 hasRelatedWork W1997037720 @default.
• W1973504804 hasRelatedWork W2018164536 @default.
• W1973504804 hasRelatedWork W2026026730 @default.
• W1973504804 hasRelatedWork W2027607287 @default.
• W1973504804 hasRelatedWork W2030027526 @default.
• W1973504804 hasRelatedWork W2033363986 @default.
• W1973504804 hasRelatedWork W2049287663 @default.
• W1973504804 hasRelatedWork W2059861550 @default.
• W1973504804 hasRelatedWork W2083502548 @default.
• W1973504804 hasRelatedWork W2091095407 @default.
• W1973504804 hasRelatedWork W2150765045 @default.
• W1973504804 hasRelatedWork W2167863991 @default.
• W1973504804 hasRelatedWork W2170170347 @default.
• W1973504804 hasRelatedWork W2406099077 @default.
• W1973504804 isParatext "false" @default.
• W1973504804 isRetracted "false" @default.
• W1973504804 magId "1973504804" @default.

• next