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• W1973508741 abstract "Predicting protein complexes from protein-protein interaction data is becoming a fundamental problem in computational biology. The identification and characterization of protein complexes implicated are crucial to the understanding of the molecular events under normal and abnormal physiological conditions. On the other hand, large datasets of experimentally detected protein-protein interactions were determined using High-throughput experimental techniques. However, experimental data is usually liable to contain a large number of spurious interactions. Therefore, it is essential to validate these interactions before exploiting them to predict protein complexes. In this paper, we propose a novel graph mining algorithm (PEWCC) to identify such protein complexes. Firstly, the algorithm assesses the reliability of the interaction data, then predicts protein complexes based on the concept of weighted clustering coefficient. To demonstrate the effectiveness of the proposed method, the performance of PEWCC was compared to several methods. PEWCC was able to detect more matched complexes than any of the state-of-the-art methods with higher quality scores. The higher accuracy achieved by PEWCC in detecting protein complexes is a valid argument in favor of the proposed method. The datasets and programs are freely available at http://faculty.uaeu.ac.ae/nzaki/Research.htm ." @default.
• W1973508741 created "2016-06-24" @default.
• W1973508741 creator A5053002217 @default.
• W1973508741 creator A5054563598 @default.
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• W1973508741 date "2013-05-20" @default.
• W1973508741 modified "2023-10-17" @default.
• W1973508741 title "Protein complex detection using interaction reliability assessment and weighted clustering coefficient" @default.
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• W1973508741 doi "https://doi.org/10.1186/1471-2105-14-163" @default.
• W1973508741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680028" @default.
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• W1973508741 hasPublicationYear "2013" @default.
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