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- W1973508839 abstract "Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors—including those relevant to the Hedgehog, Wnt, Notch, and TGFβ pathways—and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds. Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors—including those relevant to the Hedgehog, Wnt, Notch, and TGFβ pathways—and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds." @default.
- W1973508839 created "2016-06-24" @default.
- W1973508839 creator A5003512733 @default.
- W1973508839 creator A5007226887 @default.
- W1973508839 creator A5055260746 @default.
- W1973508839 creator A5071904593 @default.
- W1973508839 creator A5080672788 @default.
- W1973508839 date "2009-10-01" @default.
- W1973508839 modified "2023-10-17" @default.
- W1973508839 title "Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways" @default.
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