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• W1973513517 abstract "Sequencing error presents a significant challenge to population genetic analyses using low-coverage sequence in general and single-pass reads in particular. Bias in parameter estimates becomes severe when the level of polymorphism (signal) is low relative to the amount of error (noise). Choosing an arbitrary quality score cutoff yields biased estimates, particularly with newer, non-Sanger sequencing technologies that have different quality score distributions. We propose a rule of thumb to judge when a given threshold will lead to significant bias and suggest alternative approaches that reduce bias." @default.
• W1973513517 created "2016-06-24" @default.
• W1973513517 creator A5020423008 @default.
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• W1973513517 date "2007-11-13" @default.
• W1973513517 modified "2023-09-25" @default.
• W1973513517 title "Accounting for Bias from Sequencing Error in Population Genetic Estimates" @default.
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• W1973513517 doi "https://doi.org/10.1093/molbev/msm239" @default.
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