FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973516103> ?p ?o ?g. }

• W1973516103 endingPage "972" @default.
• W1973516103 startingPage "967" @default.
• W1973516103 abstract "The effect of chlorpropamide was determined in Brattleboro diabetes insipidus (DI) rats that were injected with l-deamino-8-D-arginine vasopressin (dDAVP). Chlorpropamide augmented the antidiuretic responses to 0.78 and 1.56 ng dDAVP but not to larger doses. In an effort to explain this observation we investigated the effect of chlorpropamide on renal medullary adenylate cyclase activation by dDAVP and on phosphodiesterase activity. We found that the injection of chlorpropamide increased adenylate cyclase activation by dDAVP added in vitro to renal medullary cell membrane preparations from Brattleboro DI rats but had no effect on phosphodiesterase activity. When kidneys from Brattleboro DI rats, treated and not treated with chlorpropamide, were perfused in vitro, we found that 10 8 M dDAVP increased the concentration of cAMP in comparison to untreated and chlorpropamide-treated groups, and that chlorpropamide plus dDAVP resulted in a greater concentration of renal cAMP than was found with dDAVP alone. We believe that treatment with chlorpropamide increases dDAVP-stimulated renal medullary adenylate cyclase activity without altering phosphodiesterase activity and that this leads to increased renal cAMP concentrations. This, in turn, causes an augmented antidiuresis in response to dDAVP. (Endocrinology106: 967, 1980)" @default.
• W1973516103 created "2016-06-24" @default.
• W1973516103 creator A5000788566 @default.
• W1973516103 creator A5060926535 @default.
• W1973516103 date "1980-03-01" @default.
• W1973516103 modified "2023-09-26" @default.
• W1973516103 title "Augmentation by Chlorpropamide of l-Deamino-8-DArginine Vasopressin-Induced Antidiuresis and Stimulation of Renal Medullary Adenylate Cyclase and Accumulation of Adenosine 3′,5′-Monophosphate*" @default.
• W1973516103 cites W1602784471 @default.
• W1973516103 cites W174622014 @default.
• W1973516103 cites W1775749144 @default.
• W1973516103 cites W1965200950 @default.
• W1973516103 cites W1965714513 @default.
• W1973516103 cites W1965998447 @default.
• W1973516103 cites W1974014362 @default.
• W1973516103 cites W1977895537 @default.
• W1973516103 cites W1996036470 @default.
• W1973516103 cites W1996466550 @default.
• W1973516103 cites W1999338306 @default.
• W1973516103 cites W2010332894 @default.
• W1973516103 cites W2028066203 @default.
• W1973516103 cites W2048536648 @default.
• W1973516103 cites W2052254983 @default.
• W1973516103 cites W2077511227 @default.
• W1973516103 cites W2078493988 @default.
• W1973516103 cites W2081263241 @default.
• W1973516103 cites W2081330336 @default.
• W1973516103 cites W2097437723 @default.
• W1973516103 cites W2123213669 @default.
• W1973516103 cites W2126408020 @default.
• W1973516103 cites W2134616076 @default.
• W1973516103 cites W2149580519 @default.
• W1973516103 cites W2156190864 @default.
• W1973516103 cites W2169503005 @default.
• W1973516103 cites W2188681416 @default.
• W1973516103 cites W2261645395 @default.
• W1973516103 cites W2415555648 @default.
• W1973516103 cites W2472292285 @default.
• W1973516103 cites W2225833947 @default.
• W1973516103 doi "https://doi.org/10.1210/endo-106-3-967" @default.
• W1973516103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6243558" @default.
• W1973516103 hasPublicationYear "1980" @default.
• W1973516103 type Work @default.
• W1973516103 sameAs 1973516103 @default.
• W1973516103 citedByCount "18" @default.
• W1973516103 countsByYear W19735161032013 @default.
• W1973516103 countsByYear W19735161032016 @default.
• W1973516103 crossrefType "journal-article" @default.
• W1973516103 hasAuthorship W1973516103A5000788566 @default.
• W1973516103 hasAuthorship W1973516103A5060926535 @default.
• W1973516103 hasConcept C126322002 @default.
• W1973516103 hasConcept C134018914 @default.
• W1973516103 hasConcept C170493617 @default.
• W1973516103 hasConcept C180526460 @default.
• W1973516103 hasConcept C181199279 @default.
• W1973516103 hasConcept C185592680 @default.
• W1973516103 hasConcept C24998067 @default.
• W1973516103 hasConcept C2776370428 @default.
• W1973516103 hasConcept C2778689066 @default.
• W1973516103 hasConcept C2780069284 @default.
• W1973516103 hasConcept C2780091579 @default.
• W1973516103 hasConcept C55493867 @default.
• W1973516103 hasConcept C555293320 @default.
• W1973516103 hasConcept C62826618 @default.
• W1973516103 hasConcept C71924100 @default.
• W1973516103 hasConceptScore W1973516103C126322002 @default.
• W1973516103 hasConceptScore W1973516103C134018914 @default.
• W1973516103 hasConceptScore W1973516103C170493617 @default.
• W1973516103 hasConceptScore W1973516103C180526460 @default.
• W1973516103 hasConceptScore W1973516103C181199279 @default.
• W1973516103 hasConceptScore W1973516103C185592680 @default.
• W1973516103 hasConceptScore W1973516103C24998067 @default.
• W1973516103 hasConceptScore W1973516103C2776370428 @default.
• W1973516103 hasConceptScore W1973516103C2778689066 @default.
• W1973516103 hasConceptScore W1973516103C2780069284 @default.
• W1973516103 hasConceptScore W1973516103C2780091579 @default.
• W1973516103 hasConceptScore W1973516103C55493867 @default.
• W1973516103 hasConceptScore W1973516103C555293320 @default.
• W1973516103 hasConceptScore W1973516103C62826618 @default.
• W1973516103 hasConceptScore W1973516103C71924100 @default.
• W1973516103 hasIssue "3" @default.
• W1973516103 hasLocation W19735161031 @default.
• W1973516103 hasLocation W19735161032 @default.
• W1973516103 hasOpenAccess W1973516103 @default.
• W1973516103 hasPrimaryLocation W19735161031 @default.
• W1973516103 hasRelatedWork W1973516103 @default.
• W1973516103 hasRelatedWork W1984909019 @default.
• W1973516103 hasRelatedWork W1997926865 @default.
• W1973516103 hasRelatedWork W2000223190 @default.
• W1973516103 hasRelatedWork W2000995372 @default.
• W1973516103 hasRelatedWork W2078493988 @default.
• W1973516103 hasRelatedWork W2082380108 @default.
• W1973516103 hasRelatedWork W2155585839 @default.
• W1973516103 hasRelatedWork W2157838869 @default.
• W1973516103 hasRelatedWork W2166602181 @default.
• W1973516103 hasVolume "106" @default.
• W1973516103 isParatext "false" @default.
• W1973516103 isRetracted "false" @default.
• W1973516103 magId "1973516103" @default.

• next