Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973547089> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1973547089 endingPage "51" @default.
- W1973547089 startingPage "41" @default.
- W1973547089 abstract "Using prepubertal male New Zealand White rabbits, continuous subcutaneous insulin infusion (CSII), delivered by either an external or an implantable infusion device, resulted in significantly higher insulin antibody (I-Ab) production than bolus injection (BII). We tested the influence during CSII of (1) the insulin species, (2) the insulin diluent, (3) the materials of which the infusion devices were made and (4) the incubation of insulin in a syringe on the backs of rabbits ('sham-infusion'), with the following results: (1) beef and sulphated beef insulins produced high levels of I-Abs, while porcine and human insulins produced moderate levels; (2) with all insulins used, 0.9% NaCl and 0.9% NaCl with 24-26 mmol NaHCO3 added, produced high levels of I-Ab. A buffer containing 0.7% NaCl, 0.136% sodium acetate trihydrate and 0.1% methyl-p-hydroxybenzoate and a buffer containing 16 mg/ml glycerol and 2 mg/ml phenol, produced highly significantly lower I-Abs (P less than 0.001); (3) insulin glass syringes produced much lower I-Ab levels than in standard polypropylene syringes and (4) polypropylene syringes in a 'sham-infusion' technique, resulted in intermediate levels of insulin antibodies [(P less than 0.02) vs CSII; (P less than 0.005) vs BII]. Our data suggest that insulin immunogenicity is influenced by all four factors tested. We suggest that benefits of CSII therapy may be attenuated unless a best possible control of these factors is achieved." @default.
- W1973547089 created "2016-06-24" @default.
- W1973547089 creator A5004353111 @default.
- W1973547089 creator A5029389225 @default.
- W1973547089 creator A5074110746 @default.
- W1973547089 date "1991-01-01" @default.
- W1973547089 modified "2023-09-23" @default.
- W1973547089 title "Continuous subcutaneous insulin infusion (CSII) and insulin antibodies in rabbits" @default.
- W1973547089 cites W1927182153 @default.
- W1973547089 cites W1966902856 @default.
- W1973547089 cites W1970905156 @default.
- W1973547089 cites W1980302076 @default.
- W1973547089 cites W1996220552 @default.
- W1973547089 cites W1998498176 @default.
- W1973547089 cites W2007449704 @default.
- W1973547089 cites W2035170098 @default.
- W1973547089 cites W2042314257 @default.
- W1973547089 cites W2053105559 @default.
- W1973547089 cites W2060264538 @default.
- W1973547089 cites W2079170821 @default.
- W1973547089 cites W2084811082 @default.
- W1973547089 cites W2085158757 @default.
- W1973547089 cites W2135293910 @default.
- W1973547089 cites W2135934500 @default.
- W1973547089 cites W2135953156 @default.
- W1973547089 cites W2143969840 @default.
- W1973547089 cites W2144201353 @default.
- W1973547089 cites W2168379904 @default.
- W1973547089 cites W2171609451 @default.
- W1973547089 cites W2396355336 @default.
- W1973547089 cites W2415429687 @default.
- W1973547089 doi "https://doi.org/10.1016/0168-8227(91)90129-2" @default.
- W1973547089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1855440" @default.
- W1973547089 hasPublicationYear "1991" @default.
- W1973547089 type Work @default.
- W1973547089 sameAs 1973547089 @default.
- W1973547089 citedByCount "2" @default.
- W1973547089 crossrefType "journal-article" @default.
- W1973547089 hasAuthorship W1973547089A5004353111 @default.
- W1973547089 hasAuthorship W1973547089A5029389225 @default.
- W1973547089 hasAuthorship W1973547089A5074110746 @default.
- W1973547089 hasConcept C118552586 @default.
- W1973547089 hasConcept C126322002 @default.
- W1973547089 hasConcept C134018914 @default.
- W1973547089 hasConcept C159654299 @default.
- W1973547089 hasConcept C203014093 @default.
- W1973547089 hasConcept C2776390293 @default.
- W1973547089 hasConcept C2778024521 @default.
- W1973547089 hasConcept C2778571141 @default.
- W1973547089 hasConcept C2779306644 @default.
- W1973547089 hasConcept C2779946736 @default.
- W1973547089 hasConcept C2780668416 @default.
- W1973547089 hasConcept C2780868878 @default.
- W1973547089 hasConcept C2781232474 @default.
- W1973547089 hasConcept C43376680 @default.
- W1973547089 hasConcept C555293320 @default.
- W1973547089 hasConcept C71924100 @default.
- W1973547089 hasConceptScore W1973547089C118552586 @default.
- W1973547089 hasConceptScore W1973547089C126322002 @default.
- W1973547089 hasConceptScore W1973547089C134018914 @default.
- W1973547089 hasConceptScore W1973547089C159654299 @default.
- W1973547089 hasConceptScore W1973547089C203014093 @default.
- W1973547089 hasConceptScore W1973547089C2776390293 @default.
- W1973547089 hasConceptScore W1973547089C2778024521 @default.
- W1973547089 hasConceptScore W1973547089C2778571141 @default.
- W1973547089 hasConceptScore W1973547089C2779306644 @default.
- W1973547089 hasConceptScore W1973547089C2779946736 @default.
- W1973547089 hasConceptScore W1973547089C2780668416 @default.
- W1973547089 hasConceptScore W1973547089C2780868878 @default.
- W1973547089 hasConceptScore W1973547089C2781232474 @default.
- W1973547089 hasConceptScore W1973547089C43376680 @default.
- W1973547089 hasConceptScore W1973547089C555293320 @default.
- W1973547089 hasConceptScore W1973547089C71924100 @default.
- W1973547089 hasIssue "1" @default.
- W1973547089 hasLocation W19735470891 @default.
- W1973547089 hasLocation W19735470892 @default.
- W1973547089 hasOpenAccess W1973547089 @default.
- W1973547089 hasPrimaryLocation W19735470891 @default.
- W1973547089 hasRelatedWork W1966225706 @default.
- W1973547089 hasRelatedWork W1974106130 @default.
- W1973547089 hasRelatedWork W2016328345 @default.
- W1973547089 hasRelatedWork W2042819106 @default.
- W1973547089 hasRelatedWork W2048226041 @default.
- W1973547089 hasRelatedWork W2066345847 @default.
- W1973547089 hasRelatedWork W2068166803 @default.
- W1973547089 hasRelatedWork W2166209517 @default.
- W1973547089 hasRelatedWork W2171960002 @default.
- W1973547089 hasRelatedWork W2430205611 @default.
- W1973547089 hasVolume "12" @default.
- W1973547089 isParatext "false" @default.
- W1973547089 isRetracted "false" @default.
- W1973547089 magId "1973547089" @default.
- W1973547089 workType "article" @default.