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- W1973548891 abstract "Amrinone is a selective inhibitor of phosphodiesterase fraction 3 in both cardiac and smooth muscle. Intravenous administration in humans produces increased contractility and vasodilation of venous capacitance and arterial conductance vessels. The elimination half-life in healthy patients is reported to be 2.6 to 4.1 hours, making it the only long-acting positive inotropic agent available that can be administered either as an intravenous bolus or by infusion. A low incidence of side effects, often minor, has been reported with intravenous use. Thrombocytopenia does not seem to be a problem with short-term use. Amrinone represents a new approach in the pharmacologic therapy for ventricular dysfunction following cardiac surgery." @default.
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- W1973548891 date "1989-12-01" @default.
- W1973548891 modified "2023-09-25" @default.
- W1973548891 title "Amrinone: pharmacokinetics and pharmacodynamics" @default.
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- W1973548891 doi "https://doi.org/10.1016/0888-6296(89)90054-9" @default.
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