Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973553417> ?p ?o ?g. }
- W1973553417 endingPage "118" @default.
- W1973553417 startingPage "113" @default.
- W1973553417 abstract "Alveolar macrophages (AM) obtained both from specific viral antibody-positive (VA+) rats and from specific viral antibody-negative (VA-) rats were compared for their respective capacity to produce lipoxins (LX) in a given experimental condition. Both cell preparations were incubated with (15S), 15-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid (15-HETE) in the presence of calcium ionophore A23187. The reaction mixtures were extracted and chromatographed on reverse-phase high performance liquid chromatography (RP-HPLC). Profiles of LX formation in each group were evaluated on the basis of chromatographic behavior, UV spectral characteristics (lambda max at 301 nm with shoulders at 289 nm and 317 nm), and co-elution with synthetic lipoxin A4 (LXA4) and lipoxin B4 (LXB4) standards as well as with authentic materials. The AM harvested from VA+ rats (AM-VA+) produced consistently detectable levels of LX (i.e., LXA4 and LXB4), whereas the AM from VA- rats (AM-VA-) produced no detectable LX under the same experimental condition. These results offer a possibility that elevated capacity of the AM-VA+ to produce LX may be associated with previous exposures to selected specific viral pathogens and/or with viral infections. Considering the distinct biologic properties of LX, the apparent production of the enhanced levels of LX as shown in this model system may play an important role in both pathophysiology and immunoregulatory network in virus-induced pulmonary disorder." @default.
- W1973553417 created "2016-06-24" @default.
- W1973553417 creator A5041351316 @default.
- W1973553417 date "1990-08-01" @default.
- W1973553417 modified "2023-10-09" @default.
- W1973553417 title "Elevated Formation of Lipoxins in Viral Antibody-positive Rat Alveolar Macrophages" @default.
- W1973553417 cites W1494464010 @default.
- W1973553417 cites W1531198291 @default.
- W1973553417 cites W1569167561 @default.
- W1973553417 cites W1627085285 @default.
- W1973553417 cites W1639313500 @default.
- W1973553417 cites W1664417331 @default.
- W1973553417 cites W1883650154 @default.
- W1973553417 cites W1894302233 @default.
- W1973553417 cites W1971402663 @default.
- W1973553417 cites W1984907346 @default.
- W1973553417 cites W1989076522 @default.
- W1973553417 cites W1993260002 @default.
- W1973553417 cites W2002772586 @default.
- W1973553417 cites W2007096194 @default.
- W1973553417 cites W2010470278 @default.
- W1973553417 cites W2016742630 @default.
- W1973553417 cites W2016870714 @default.
- W1973553417 cites W2023125766 @default.
- W1973553417 cites W2024176341 @default.
- W1973553417 cites W2027432748 @default.
- W1973553417 cites W2030397149 @default.
- W1973553417 cites W2037263991 @default.
- W1973553417 cites W2053226051 @default.
- W1973553417 cites W2054584111 @default.
- W1973553417 cites W2064557896 @default.
- W1973553417 cites W2065134394 @default.
- W1973553417 cites W2065294999 @default.
- W1973553417 cites W2070558900 @default.
- W1973553417 cites W2080718428 @default.
- W1973553417 cites W2099192757 @default.
- W1973553417 cites W2110954537 @default.
- W1973553417 cites W2125884532 @default.
- W1973553417 cites W2236469795 @default.
- W1973553417 cites W2316646354 @default.
- W1973553417 cites W2331980604 @default.
- W1973553417 cites W2409628645 @default.
- W1973553417 cites W2417736203 @default.
- W1973553417 cites W2443621862 @default.
- W1973553417 cites W308633775 @default.
- W1973553417 cites W72079153 @default.
- W1973553417 cites W84041608 @default.
- W1973553417 doi "https://doi.org/10.1165/ajrcmb/3.2.113" @default.
- W1973553417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2116155" @default.
- W1973553417 hasPublicationYear "1990" @default.
- W1973553417 type Work @default.
- W1973553417 sameAs 1973553417 @default.
- W1973553417 citedByCount "13" @default.
- W1973553417 countsByYear W19735534172014 @default.
- W1973553417 countsByYear W19735534172015 @default.
- W1973553417 countsByYear W19735534172016 @default.
- W1973553417 countsByYear W19735534172020 @default.
- W1973553417 countsByYear W19735534172021 @default.
- W1973553417 countsByYear W19735534172022 @default.
- W1973553417 crossrefType "journal-article" @default.
- W1973553417 hasAuthorship W1973553417A5041351316 @default.
- W1973553417 hasConcept C10162356 @default.
- W1973553417 hasConcept C134018914 @default.
- W1973553417 hasConcept C159654299 @default.
- W1973553417 hasConcept C178790620 @default.
- W1973553417 hasConcept C179998833 @default.
- W1973553417 hasConcept C185592680 @default.
- W1973553417 hasConcept C203014093 @default.
- W1973553417 hasConcept C2522874641 @default.
- W1973553417 hasConcept C43617362 @default.
- W1973553417 hasConcept C519063684 @default.
- W1973553417 hasConcept C55493867 @default.
- W1973553417 hasConcept C86803240 @default.
- W1973553417 hasConceptScore W1973553417C10162356 @default.
- W1973553417 hasConceptScore W1973553417C134018914 @default.
- W1973553417 hasConceptScore W1973553417C159654299 @default.
- W1973553417 hasConceptScore W1973553417C178790620 @default.
- W1973553417 hasConceptScore W1973553417C179998833 @default.
- W1973553417 hasConceptScore W1973553417C185592680 @default.
- W1973553417 hasConceptScore W1973553417C203014093 @default.
- W1973553417 hasConceptScore W1973553417C2522874641 @default.
- W1973553417 hasConceptScore W1973553417C43617362 @default.
- W1973553417 hasConceptScore W1973553417C519063684 @default.
- W1973553417 hasConceptScore W1973553417C55493867 @default.
- W1973553417 hasConceptScore W1973553417C86803240 @default.
- W1973553417 hasIssue "2" @default.
- W1973553417 hasLocation W19735534171 @default.
- W1973553417 hasLocation W19735534172 @default.
- W1973553417 hasOpenAccess W1973553417 @default.
- W1973553417 hasPrimaryLocation W19735534171 @default.
- W1973553417 hasRelatedWork W1499732058 @default.
- W1973553417 hasRelatedWork W1568635045 @default.
- W1973553417 hasRelatedWork W1967736413 @default.
- W1973553417 hasRelatedWork W1989673413 @default.
- W1973553417 hasRelatedWork W2048213734 @default.
- W1973553417 hasRelatedWork W2140812068 @default.
- W1973553417 hasRelatedWork W2349232521 @default.
- W1973553417 hasRelatedWork W2371794589 @default.