FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973556646> ?p ?o ?g. }

• W1973556646 endingPage "162" @default.
• W1973556646 startingPage "158" @default.
• W1973556646 abstract "The T-helper (Th)1/Th2 imbalance has been demonstrated to be involved in chronic heart failure (CHF). We sought to determine whether atorvastatin exhibited any effect on CHF through modulating the Th1/Th2 response.We measured serum concentrations of interleukin (IL)-12, -18, interferon (IFN)-gamma, IL-4, and IL-10 from 20 controls and 72 patients with nonischemic CHF by enzyme-linked immunosorbent assay. To investigate the effect of atorvastatin in vivo, CHF patients were either classified into a usual therapy group (n = 35) or usual therapy plus atorvastatin (10 mg/day) group (n = 37). Patient serum levels of IFN-gamma and IL-4 were measured at time of admission and 2 weeks after treatment. Peripheral blood mononuclear cells from patients of CHF group were cultured in the presence or absence of atorvastatin (0, 0.4, 1, and 4 micromol/L) in vitro, and IFN-gamma and IL-4 levels were detected. Serum levels of IL-12, IL-18, and IFN-gamma were significantly higher in the CHF group than in the control group. The levels of IFN-gamma and the ratios of IFN-gamma:IL-4 were significantly decreased with atorvastatin treatment both in vivo and in vitro, whereas levels of IL-4 did not differ significantly.Th1 polarization exists in patients with CHF, and atorvastatin can modulate the Th1/Th2 response through inhibiting Th1 cytokine production." @default.
• W1973556646 created "2016-06-24" @default.
• W1973556646 creator A5000529473 @default.
• W1973556646 creator A5002600613 @default.
• W1973556646 creator A5005007413 @default.
• W1973556646 creator A5013953637 @default.
• W1973556646 creator A5016619525 @default.
• W1973556646 creator A5026170465 @default.
• W1973556646 creator A5032739463 @default.
• W1973556646 creator A5035064408 @default.
• W1973556646 creator A5062413297 @default.
• W1973556646 creator A5063341597 @default.
• W1973556646 creator A5083973304 @default.
• W1973556646 date "2009-03-01" @default.
• W1973556646 modified "2023-09-28" @default.
• W1973556646 title "Atorvastatin Modulates Th1/Th2 Response in Patients With Chronic Heart Failure" @default.
• W1973556646 cites W1525331105 @default.
• W1973556646 cites W1976204695 @default.
• W1973556646 cites W1977595948 @default.
• W1973556646 cites W1980857453 @default.
• W1973556646 cites W1981174960 @default.
• W1973556646 cites W1983679827 @default.
• W1973556646 cites W1988140970 @default.
• W1973556646 cites W1990793066 @default.
• W1973556646 cites W1998065531 @default.
• W1973556646 cites W2006201248 @default.
• W1973556646 cites W2014355830 @default.
• W1973556646 cites W2015984692 @default.
• W1973556646 cites W2031579146 @default.
• W1973556646 cites W2059136699 @default.
• W1973556646 cites W2059816227 @default.
• W1973556646 cites W2062079696 @default.
• W1973556646 cites W2072169002 @default.
• W1973556646 cites W2079217588 @default.
• W1973556646 cites W2082838924 @default.
• W1973556646 cites W2092236891 @default.
• W1973556646 cites W2109963121 @default.
• W1973556646 cites W2117538430 @default.
• W1973556646 cites W2127688157 @default.
• W1973556646 cites W2169355643 @default.
• W1973556646 cites W2608539973 @default.
• W1973556646 cites W4237188380 @default.
• W1973556646 doi "https://doi.org/10.1016/j.cardfail.2008.10.001" @default.
• W1973556646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19643369" @default.
• W1973556646 hasPublicationYear "2009" @default.
• W1973556646 type Work @default.
• W1973556646 sameAs 1973556646 @default.
• W1973556646 citedByCount "45" @default.
• W1973556646 countsByYear W19735566462012 @default.
• W1973556646 countsByYear W19735566462013 @default.
• W1973556646 countsByYear W19735566462014 @default.
• W1973556646 countsByYear W19735566462015 @default.
• W1973556646 countsByYear W19735566462016 @default.
• W1973556646 countsByYear W19735566462017 @default.
• W1973556646 countsByYear W19735566462018 @default.
• W1973556646 countsByYear W19735566462019 @default.
• W1973556646 countsByYear W19735566462020 @default.
• W1973556646 countsByYear W19735566462021 @default.
• W1973556646 countsByYear W19735566462022 @default.
• W1973556646 crossrefType "journal-article" @default.
• W1973556646 hasAuthorship W1973556646A5000529473 @default.
• W1973556646 hasAuthorship W1973556646A5002600613 @default.
• W1973556646 hasAuthorship W1973556646A5005007413 @default.
• W1973556646 hasAuthorship W1973556646A5013953637 @default.
• W1973556646 hasAuthorship W1973556646A5016619525 @default.
• W1973556646 hasAuthorship W1973556646A5026170465 @default.
• W1973556646 hasAuthorship W1973556646A5032739463 @default.
• W1973556646 hasAuthorship W1973556646A5035064408 @default.
• W1973556646 hasAuthorship W1973556646A5062413297 @default.
• W1973556646 hasAuthorship W1973556646A5063341597 @default.
• W1973556646 hasAuthorship W1973556646A5083973304 @default.
• W1973556646 hasConcept C126322002 @default.
• W1973556646 hasConcept C134018914 @default.
• W1973556646 hasConcept C137061746 @default.
• W1973556646 hasConcept C150903083 @default.
• W1973556646 hasConcept C185592680 @default.
• W1973556646 hasConcept C202751555 @default.
• W1973556646 hasConcept C203014093 @default.
• W1973556646 hasConcept C207001950 @default.
• W1973556646 hasConcept C2777482532 @default.
• W1973556646 hasConcept C2778198053 @default.
• W1973556646 hasConcept C2778690821 @default.
• W1973556646 hasConcept C2780841837 @default.
• W1973556646 hasConcept C55493867 @default.
• W1973556646 hasConcept C71924100 @default.
• W1973556646 hasConcept C86803240 @default.
• W1973556646 hasConcept C90924648 @default.
• W1973556646 hasConceptScore W1973556646C126322002 @default.
• W1973556646 hasConceptScore W1973556646C134018914 @default.
• W1973556646 hasConceptScore W1973556646C137061746 @default.
• W1973556646 hasConceptScore W1973556646C150903083 @default.
• W1973556646 hasConceptScore W1973556646C185592680 @default.
• W1973556646 hasConceptScore W1973556646C202751555 @default.
• W1973556646 hasConceptScore W1973556646C203014093 @default.
• W1973556646 hasConceptScore W1973556646C207001950 @default.
• W1973556646 hasConceptScore W1973556646C2777482532 @default.
• W1973556646 hasConceptScore W1973556646C2778198053 @default.
• W1973556646 hasConceptScore W1973556646C2778690821 @default.

• next