FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973559978> ?p ?o ?g. }

• W1973559978 endingPage "S88" @default.
• W1973559978 startingPage "S83" @default.
• W1973559978 abstract "This article focuses on our current understanding of the role of activated coagulation factor VII (FVIIa) in coagulation, the current evidence regarding the efficacy and safety of recombinant FVIIa (rFVIIa), and thoughts regarding the use of rFVIIa in spine surgery. rFVIIa is approved in many countries (including the European Union and the USA) for patients with hemophilia and inhibitors (antibodies) to coagulation factors VIII or IX. High circulating concentrations of FVIIa, achieved by exogenous administration, initiate hemostasis by combining with tissue factor at the site of injury, producing thrombin, activating platelets and coagulation factors II, IX and X, thus providing for the full thrombin burst that is essential for hemostasis. This “bypass” therapy has led some clinicians to use rFVIIa “off-label” for disorders of hemostasis other than hemophilia. Based on clinical experience, case reports and limited information from clinical trials, rFVIIa may be efficacious in states of decreased concentration of coagulation factors, thrombocytopenia, and at least some states of altered platelet function. The former two can occur intra-operatively during spinal surgery as a consequence of substantial blood loss and normal consumption. Preliminary reports have indicated that rFVIIa does not increase the perioperative incidence of thromboembolic events. However, full reports from large clinical trials regarding the efficacy and safety of rFVIIa in settings other than hemophilia have yet to appear in peer-reviewed publications. Until adequate data demonstrating safety and efficacy are fully reported, it would seem appropriate to reserve the use of rFVIIa in spinal surgery to those instances where conventional therapy cannot provide adequate hemostasis, and “rescue” therapy is required." @default.
• W1973559978 created "2016-06-24" @default.
• W1973559978 creator A5045833577 @default.
• W1973559978 date "2004-05-25" @default.
• W1973559978 modified "2023-09-25" @default.
• W1973559978 title "The use of recombinant activated coagulation factor VII for spine surgery" @default.
• W1973559978 cites W1264942373 @default.
• W1973559978 cites W1571170149 @default.
• W1973559978 cites W1964307571 @default.
• W1973559978 cites W1964654907 @default.
• W1973559978 cites W1971299368 @default.
• W1973559978 cites W1975210832 @default.
• W1973559978 cites W1983707924 @default.
• W1973559978 cites W1986547366 @default.
• W1973559978 cites W1993430353 @default.
• W1973559978 cites W1997907146 @default.
• W1973559978 cites W1999454415 @default.
• W1973559978 cites W2017212158 @default.
• W1973559978 cites W2018784308 @default.
• W1973559978 cites W2019179935 @default.
• W1973559978 cites W2023939618 @default.
• W1973559978 cites W2029631224 @default.
• W1973559978 cites W2037652834 @default.
• W1973559978 cites W2038924841 @default.
• W1973559978 cites W2038961796 @default.
• W1973559978 cites W2039466802 @default.
• W1973559978 cites W2045000983 @default.
• W1973559978 cites W2046780165 @default.
• W1973559978 cites W2046936517 @default.
• W1973559978 cites W2047010931 @default.
• W1973559978 cites W2049081993 @default.
• W1973559978 cites W2057007282 @default.
• W1973559978 cites W2069681619 @default.
• W1973559978 cites W2069798347 @default.
• W1973559978 cites W2074169411 @default.
• W1973559978 cites W2074228619 @default.
• W1973559978 cites W2078875217 @default.
• W1973559978 cites W2086977057 @default.
• W1973559978 cites W2091908750 @default.
• W1973559978 cites W2115696894 @default.
• W1973559978 cites W2134417756 @default.
• W1973559978 cites W2136412373 @default.
• W1973559978 cites W2144537409 @default.
• W1973559978 cites W2158656134 @default.
• W1973559978 cites W2255950219 @default.
• W1973559978 cites W2409726607 @default.
• W1973559978 cites W2411364861 @default.
• W1973559978 cites W2414916611 @default.
• W1973559978 cites W2509275080 @default.
• W1973559978 cites W2832953311 @default.
• W1973559978 doi "https://doi.org/10.1007/s00586-004-0736-y" @default.
• W1973559978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3592181" @default.
• W1973559978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15160317" @default.
• W1973559978 hasPublicationYear "2004" @default.
• W1973559978 type Work @default.
• W1973559978 sameAs 1973559978 @default.
• W1973559978 citedByCount "15" @default.
• W1973559978 countsByYear W19735599782012 @default.
• W1973559978 countsByYear W19735599782014 @default.
• W1973559978 countsByYear W19735599782018 @default.
• W1973559978 countsByYear W19735599782020 @default.
• W1973559978 countsByYear W19735599782021 @default.
• W1973559978 countsByYear W19735599782022 @default.
• W1973559978 crossrefType "journal-article" @default.
• W1973559978 hasAuthorship W1973559978A5045833577 @default.
• W1973559978 hasBestOaLocation W19735599782 @default.
• W1973559978 hasConcept C126322002 @default.
• W1973559978 hasConcept C141071460 @default.
• W1973559978 hasConcept C177713679 @default.
• W1973559978 hasConcept C2778382381 @default.
• W1973559978 hasConcept C2778589496 @default.
• W1973559978 hasConcept C2778961111 @default.
• W1973559978 hasConcept C31174226 @default.
• W1973559978 hasConcept C42219234 @default.
• W1973559978 hasConcept C535046627 @default.
• W1973559978 hasConcept C71924100 @default.
• W1973559978 hasConcept C89560881 @default.
• W1973559978 hasConceptScore W1973559978C126322002 @default.
• W1973559978 hasConceptScore W1973559978C141071460 @default.
• W1973559978 hasConceptScore W1973559978C177713679 @default.
• W1973559978 hasConceptScore W1973559978C2778382381 @default.
• W1973559978 hasConceptScore W1973559978C2778589496 @default.
• W1973559978 hasConceptScore W1973559978C2778961111 @default.
• W1973559978 hasConceptScore W1973559978C31174226 @default.
• W1973559978 hasConceptScore W1973559978C42219234 @default.
• W1973559978 hasConceptScore W1973559978C535046627 @default.
• W1973559978 hasConceptScore W1973559978C71924100 @default.
• W1973559978 hasConceptScore W1973559978C89560881 @default.
• W1973559978 hasIssue "S01" @default.
• W1973559978 hasLocation W19735599781 @default.
• W1973559978 hasLocation W19735599782 @default.
• W1973559978 hasLocation W19735599783 @default.
• W1973559978 hasLocation W19735599784 @default.
• W1973559978 hasOpenAccess W1973559978 @default.
• W1973559978 hasPrimaryLocation W19735599781 @default.
• W1973559978 hasRelatedWork W1588076853 @default.
• W1973559978 hasRelatedWork W1963828782 @default.
• W1973559978 hasRelatedWork W2046564088 @default.

• next