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- W19735732 abstract "The death from disseminated histoplasmosis of a patient with hypogammaglobulinemia, increased susceptibility to infection, splenomegaly and leukopenia led to an investigation of his family. Three of his six living children, a thirteen year old boy and six year old fraternal twin girls, were found to have a similar syndrome without evidence of infection with histoplasmosis. The patient's father had splenomegaly but no other features of this syndrome. The other members of the family had none of these abnormalities. In the involved members the level of gamma globulins and the degree of immunologic responsiveness, while depressed, were greater than usually observed in other forms of hypogammaglobulinemia. The evidence suggests that this apparently new clinical entity is an hereditary disturbance transmitted possibly by an autosomal dominant gene. The etiological features of the known forms of hypogammaglobulinemia are reviewed and commented upon." @default.
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- W19735732 date "1960-07-01" @default.
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- W19735732 title "Familial hypogammaglobulinemia, splenomegaly and leukopenia" @default.
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- W19735732 doi "https://doi.org/10.1016/0002-9343(60)90005-x" @default.
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