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• W1973581737 abstract "We have developed a fully automated method, InterProSurf, to predict interacting amino acid residues on protein surfaces of monomeric 3D structures. Potential interacting residues are predicted based on solvent accessible surface areas, a new scale for interface propensities, and a cluster algorithm to locate surface exposed areas with high interface propensities. Previous studies have shown the importance of hydrophobic residues and specific charge distribution as characteristics for interfaces. Here we show differences in interface and surface regions of all physical chemical properties of residues as represented by five quantitative descriptors. In the current study a set of 72 protein complexes with known 3D structures were analyzed to obtain interface propensities of residues, and to find differences in the distribution of five quantitative descriptors for amino acid residues. We also investigated spatial pair correlations of solvent accessible residues in interface and surface areas, and compared log-odds ratios for interface and surface areas. A new scoring method to predict potential functional sites on the protein surface was developed and tested for a new dataset of 21 protein complexes, which were not included in the original training dataset. Empirically we found that the algorithm achieves a good balance in the accuracy of precision and sensitivity by selecting the top eight highest scoring clusters as interface regions. The performance of the method is illustrated for a dimeric ATPase of the hyperthermophile, Methanococcus jannaschii, and the capsid protein of Human Hepatitis B virus. An automated version of the method can be accessed from our web server at http://curie.utmb.edu/prosurf.html." @default.
• W1973581737 created "2016-06-24" @default.
• W1973581737 creator A5043184951 @default.
• W1973581737 creator A5055169952 @default.
• W1973581737 date "2007-09-09" @default.
• W1973581737 modified "2023-10-16" @default.
• W1973581737 title "Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces" @default.
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• W1973581737 doi "https://doi.org/10.1007/s00894-007-0237-0" @default.
• W1973581737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2628805" @default.
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