FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1973588962> ?p ?o ?g. }

• W1973588962 endingPage "18" @default.
• W1973588962 startingPage "13" @default.
• W1973588962 abstract "Abstract Retinoids are vitamin A derivatives that exert major effects on growth control, epithelial differentiation and embryonic development and, accordingly, are highly teratogenic. In HL60 myelo-monocytic or F9 embryonal carcinoma cell lines, retinoic acid (RA) turns a transformed cell line into terminally differentiated non-proliferating cells. It was only in the mid 1980s that the cloning of the retinoic acid receptors gave a molecular basis to the pleiotropic action of these compound. Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear receptors, like those for steroids or thyroid hormones. They are hormone-activated transcription factors that bind to the promoters of their target genes as RAR/RXR heterodimers and repress or activate their transcription depending on the presence of the hormone. Both retinoic acid and its three RAR (α, β, γ) receptors have close links to cancer. Retinoids have significant antitumour activities in several clinical settings, in particular in cervical, skin, head and neck cancers, neuroblastoma and oral leukoplakia, where high doses have yielded significant improvements. A better understanding of the function targeted in the cancer cell and the receptor involved may lead to more specific drugs. Alterations of RARβ expression were reported in a variety of tumors and have suggested that it may act as a tumour suppressor. The clearest illustration of how alterations in RAR structure are linked to cancer is acute promyelocytic leukemia (APL), where a chromosome translocation fuses the PML gene to that of RARα, creating a PML/RARα fusion protein. Strikingly, in contrast, the previous malignancies that are RA-responsive, APL cells undergo terminal differentiation ex vivo or in vivo, similar to HL60 or F9 cells. APL therefore became the paradigm for differentiation therapy. Remarkably, APL is also exquisitely sensitive to arsenic trioxide and both RA and arsenic directly target the PML/RARα fusion protein, identifying the first example of oncogene-targeted therapies. Animal models have helped model the effects of these drugs and provide invaluable preclinical systems for one of the best understood malignancies to date." @default.
• W1973588962 created "2016-06-24" @default.
• W1973588962 creator A5015233518 @default.
• W1973588962 date "2003-09-01" @default.
• W1973588962 modified "2023-09-25" @default.
• W1973588962 title "Retinoids and retinoic acid receptor in cancer" @default.
• W1973588962 cites W1486948598 @default.
• W1973588962 cites W1517778647 @default.
• W1973588962 cites W1520661990 @default.
• W1973588962 cites W1546386885 @default.
• W1973588962 cites W1550565578 @default.
• W1973588962 cites W1551972473 @default.
• W1973588962 cites W1553544241 @default.
• W1973588962 cites W1554600230 @default.
• W1973588962 cites W1562107474 @default.
• W1973588962 cites W1632166816 @default.
• W1973588962 cites W1779679253 @default.
• W1973588962 cites W1854733189 @default.
• W1973588962 cites W1909732837 @default.
• W1973588962 cites W1964224609 @default.
• W1973588962 cites W1975647987 @default.
• W1973588962 cites W1977662716 @default.
• W1973588962 cites W1979895333 @default.
• W1973588962 cites W2037903080 @default.
• W1973588962 cites W2042425638 @default.
• W1973588962 cites W2051663421 @default.
• W1973588962 cites W2068589658 @default.
• W1973588962 cites W2068876833 @default.
• W1973588962 cites W2079526924 @default.
• W1973588962 cites W2101730597 @default.
• W1973588962 cites W2103668513 @default.
• W1973588962 cites W2103728018 @default.
• W1973588962 cites W2107954651 @default.
• W1973588962 cites W2108362314 @default.
• W1973588962 cites W2117568376 @default.
• W1973588962 cites W2134819449 @default.
• W1973588962 cites W2162589082 @default.
• W1973588962 cites W2171204713 @default.
• W1973588962 cites W2184391500 @default.
• W1973588962 cites W2261355130 @default.
• W1973588962 cites W2324273146 @default.
• W1973588962 cites W2443384920 @default.
• W1973588962 cites W26198858 @default.
• W1973588962 cites W4230033805 @default.
• W1973588962 cites W4242138200 @default.
• W1973588962 doi "https://doi.org/10.1016/s1359-6349(03)00010-7" @default.
• W1973588962 hasPublicationYear "2003" @default.
• W1973588962 type Work @default.
• W1973588962 sameAs 1973588962 @default.
• W1973588962 citedByCount "7" @default.
• W1973588962 countsByYear W19735889622016 @default.
• W1973588962 countsByYear W19735889622019 @default.
• W1973588962 countsByYear W19735889622020 @default.
• W1973588962 countsByYear W19735889622021 @default.
• W1973588962 countsByYear W19735889622022 @default.
• W1973588962 crossrefType "journal-article" @default.
• W1973588962 hasAuthorship W1973588962A5015233518 @default.
• W1973588962 hasConcept C104317684 @default.
• W1973588962 hasConcept C119775778 @default.
• W1973588962 hasConcept C120197328 @default.
• W1973588962 hasConcept C121608353 @default.
• W1973588962 hasConcept C126322002 @default.
• W1973588962 hasConcept C139522298 @default.
• W1973588962 hasConcept C170493617 @default.
• W1973588962 hasConcept C185592680 @default.
• W1973588962 hasConcept C19431177 @default.
• W1973588962 hasConcept C2781121885 @default.
• W1973588962 hasConcept C502942594 @default.
• W1973588962 hasConcept C55493867 @default.
• W1973588962 hasConcept C71924100 @default.
• W1973588962 hasConcept C98274493 @default.
• W1973588962 hasConceptScore W1973588962C104317684 @default.
• W1973588962 hasConceptScore W1973588962C119775778 @default.
• W1973588962 hasConceptScore W1973588962C120197328 @default.
• W1973588962 hasConceptScore W1973588962C121608353 @default.
• W1973588962 hasConceptScore W1973588962C126322002 @default.
• W1973588962 hasConceptScore W1973588962C139522298 @default.
• W1973588962 hasConceptScore W1973588962C170493617 @default.
• W1973588962 hasConceptScore W1973588962C185592680 @default.
• W1973588962 hasConceptScore W1973588962C19431177 @default.
• W1973588962 hasConceptScore W1973588962C2781121885 @default.
• W1973588962 hasConceptScore W1973588962C502942594 @default.
• W1973588962 hasConceptScore W1973588962C55493867 @default.
• W1973588962 hasConceptScore W1973588962C71924100 @default.
• W1973588962 hasConceptScore W1973588962C98274493 @default.
• W1973588962 hasIssue "2" @default.
• W1973588962 hasLocation W19735889621 @default.
• W1973588962 hasOpenAccess W1973588962 @default.
• W1973588962 hasPrimaryLocation W19735889621 @default.
• W1973588962 hasRelatedWork W1512192410 @default.
• W1973588962 hasRelatedWork W1554640292 @default.
• W1973588962 hasRelatedWork W1581075759 @default.
• W1973588962 hasRelatedWork W1596810679 @default.
• W1973588962 hasRelatedWork W2128069335 @default.
• W1973588962 hasRelatedWork W2143087546 @default.
• W1973588962 hasRelatedWork W2296464360 @default.
• W1973588962 hasRelatedWork W2357981711 @default.
• W1973588962 hasRelatedWork W2409420542 @default.

• next