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- W1973608250 abstract "Antibiotic action.-As with most drugs, the fundamental mode of action of penicillin is not clear. Two superficial facts are well known, i.e., that gram positive bacteria are more susceptible than gram negative and that the division and growth of bacteria are im peded with the formation of bizarre forms when early death or lysis is not produced. Pandalai & George (1) associate these effects with an interference with the nucleic acid metabolism of the bac teria, which coincides with the observation that gram positiveness is associated with the presence of magnesium ribonucleate. Gale and co-workers in a series of papers (2) show that gram positive organisms (staphylococci) require an external source of glutamic acid, and that the assimilatory mechanism is blocked by penicillin. The same microbes, made highly resistant to penicillin, become like gram negative bacteria and are able to synthesize their own glutamic acid. These two views may be compatible if it is assumed that the glutamic acid becomes a constituent of nucleoprotein. A paradoxical effect has been reported by Eagle (3) and Pratt & Dufrenoy (4), in which high concentrations of penicillin, in vitro, are less effective against several common microorganisms than lower concentrations. Still lower concentrations, of course, are again less effective. The latter authors also note an enhancement of effect when traces of cobalt are present, perhaps because this element stimulates growth of the bacteria and thereby increases their susceptibility to penicillin." @default.
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- W1973608250 date "1949-10-01" @default.
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- W1973608250 title "ACTIONS OF ANTIBIOTICS IN VIVO" @default.
- W1973608250 doi "https://doi.org/10.1146/annurev.mi.03.100149.001033" @default.
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